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XK Antibody

  • 货号：
    CSB-PA908755
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA908755(XK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA908755(XK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human normal liver and placenta tissue, Primary antibody: CSB-PA908755(XK Antibody) at dilution 1/350 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P51811
  • 基因名：
    XK
  • 别名：
    XK antibody; XKR1 antibody; XRG1 antibody; Membrane transport protein XK antibody; Kell complex 37 kDa component antibody; Kx antigen antibody; XK-related protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human XK
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:20-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.
  • 基因功能参考文献：
    1. the expression of KX is critical to normal morphology, and null mutations are associated with the McLeod neuroacanthocytosis syndrome. PMID: 26308465
    2. The XK gene was not linked to hypermutability in red cells from patients with paroxysmal nocturnal hemoglobinuria. PMID: 24816235
    3. study reports the clinical findings and a novel nonsense hemizygous mutation, c.154C>T (p.Gln52X) at exon 1 of XK gene in a Taiwanese family with McLeod syndrome PMID: 24635891
    4. Novel XK protein mutations are reported in two patients who exhibit typical clinical characteristics of McLeod syndrome. PMID: 21463873
    5. This study identified one non-synonymous and one intron variant in mood disorder and schizophrenia subjects, respectively, in XK. PMID: 21145924
    6. In human cortex, the results show expression of XK in cortical neurons with an apparent cytoplasmic localization. PMID: 17379193
    7. Sequence analysis demonstrated a 5 bp deletion in exon 2 of the XK gene in McLeod syndrome. PMID: 17469188

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  • 相关疾病：
    McLeod syndrome (MLS)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    XK family
  • 组织特异性：
    High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver, and kidney.
  • 数据库链接：

    HGNC: 12811

    OMIM: 300842

    KEGG: hsa:7504

    STRING: 9606.ENSP00000367879

    UniGene: Hs.78919