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XRCC2 Antibody

  • 货号：
    CSB-PA004530
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using XRCC2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43543
  • 基因名：
    XRCC2
  • 别名：
    DKFZp781P0919 antibody; DNA repair protein XRCC2 antibody; X ray repair complementing defective repair in Chinese hamster cells 2 antibody; X ray repair cross complementing protein 2 antibody; X-ray repair cross-complementing protein 2 antibody; Xrcc2 antibody; XRCC2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human XRCC2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
  • 基因功能参考文献：
    1. XRCC2 rs3218408 was related with increased risk of colorectal cancer. PMID: 29748531
    2. Results identified a significant relationship between SNP rs3218536 of XRCC2 and an increased risk of endometrial cancer development. PMID: 30194171
    3. Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk. PMID: 28779002
    4. meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of ovarian cancer PMID: 27863412
    5. Study has shown that most rare XRCC2 missense variants have little effect on XRCC2 protein function and are unlikely to be associated with familial and early-onset breast cancer. PMID: 27233470
    6. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms PMID: 26300006
    7. XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 paralog so identified. XRCC2 is required to maintain levels of other RAD51 paralogs that are normally present in XRCC2-RAD51B-C-D complex. PMID: 27208205
    8. Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma. PMID: 27356695
    9. Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women. PMID: 26801223
    10. Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients. PMID: 26320178
    11. The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis) PMID: 26400309
    12. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51, RAD51B, XRCC2 and XRCC3. PMID: 26339569
    13. In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population. PMID: 24728564
    14. XRCC2 protein expression of colorectal cancer Chinese Han patients with CT/TT genotypes were significantly higher than CC genotype. PMID: 25304007
    15. The GA genotype of the Arg188His polymorphism of XRCC2 was associated with increased risk of breast cancer in a Pakistani cohort. PMID: 25556451
    16. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met in stomach cancer patients who lived in North Eastern Turkey and in controls. PMID: 25428673
    17. Links the SNP -41657C/T (rs718282) of the XRCC2 gene with endometrial carcinoma in Polish women. PMID: 26017882
    18. Our data suggests that deregulation of XRCC2 in breast cancer has the potential to predict lymph node metastasis PMID: 25159888
    19. A relationship was identified between XRCC2-41657C/T polymorphism and the incidence of ovarian cancer. PMID: 25355640
    20. impact of XRCC2 Arg188His polymorphism on cancer susceptibility PMID: 24621646
    21. Interaction of tobacco and polymorphisms of XRCC1 and XRCC2 increases the risk of head and neck squamous cell carcinoma in northeast Indian population.The XRCC2 Arg188His polymorphism was associated with increased risk of this cancer. PMID: 24958516
    22. High XRCC2 expression promotes CRC cell proliferation and enriches cells in the G0/G1 phase but inhibits apoptosis. PMID: 25526472
    23. Our data suggest that the suppression of XRCC2 expression rendered colon tumor cells more sensitive to radiation therapy in vitro and in vivo. PMID: 24481064
    24. Genetic variants in XRCC2 are not associated with soft-tissue sarcoma. PMID: 24189466
    25. current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer PMID: 24414483
    26. Studied whether the double strand break gene polymorphisms XRCC2 R188H G>A (rs3218536), XRCC3 T241M C>T (rs861539) and R243H G>A (rs77381814) are associated with cervical cancer in Argentine women. PMID: 23539294
    27. Our data do not confirm an association between XRCC2 variants and breast cancer risk, although a relative risk smaller than two could not be excluded. PMID: 23054243
    28. polymorphisms in XRCC2 do not contribute to cancer risk in a population of Lynch syndrome patients with colorectal cancer PMID: 21974800
    29. The results support the hypothesis that polymorphism of XRCC2 may be associated with the incidence of sporadic breast cancer in Polish women. PMID: 22611952
    30. The identification of XRCC2 as a breast cancer susceptibility gene thus increases the proportion of breast cancers that are associated with homologous recombination-DNA-repair dysfunction and Fanconi anemia. PMID: 22464251
    31. These findings suggest that XRCC2 SNPs may influence breast cancer risk and survival. PMID: 21632523
    32. The Arg188His polymorphism of the XRCC2 gene can modify the risk of colorectal cancer. PMID: 21104022
    33. Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle. PMID: 21276791
    34. the present meta-analysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk PMID: 20127279
    35. An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. PMID: 20189471
    36. may influence the repair capacity of breast cancer patients and, in turn, confer genetic predisposition to disease PMID: 20004634
    37. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. PMID: 11834724
    38. a critical role in homologous recombination repair PMID: 14645207
    39. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51 PMID: 15123651
    40. Finds no association between XRCC2 R188H polymorphism and risk of colorectal adenoma. PMID: 15184273
    41. Considering that the XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk. PMID: 17141189
    42. possible association of single nucleotide polymorphism at the 41657C/T position and 4234G/C position of XRCC2 with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) PMID: 17922422
    43. polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancer PMID: 17986315
    44. investigated the possible association of three SNPs, XRCC2 C41657T, XRCC2 G4234C and XRCC3 A17893G with susceptibility to esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in a population of northern China PMID: 18046624
    45. Findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer PMID: 18383855
    46. The snp XRCC2 rs3218536 showd some evidence of a protective association for the rare allele in progesterone receptor positive breast neoplasms. PMID: 19064565
    47. Investigation supports a role for XRCC2 in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors. PMID: 19690184
    48. Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19127255

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  • 相关疾病：
    Fanconi anemia, complementation group U (FANCU)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    RecA family, RAD51 subfamily
  • 数据库链接：

    HGNC: 12829

    OMIM: 600375

    KEGG: hsa:7516

    STRING: 9606.ENSP00000352271

    UniGene: Hs.647093