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YOD1 Antibody

  • 货号：
    CSB-PA713352LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA713352LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) YOD1 Polyclonal antibody
  • Uniprot No.：
    Q5VVQ6
  • 基因名：
  • 别名：
    DUBA-8 antibody; DUBA8 antibody; HIN-7 antibody; HIV-1-induced protease 7 antibody; HsHIN7 antibody; OTU domain containing 2 antibody; OTU domain-containing protein 2 antibody; OTU1_HUMAN antibody; OTUD2 antibody; PRO0907 antibody; RP11-164O23.1 antibody; Ubiquitin thioesterase OTU1 antibody; yod1 antibody; YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) antibody; YOD1 OTU deubiquinating enzyme 1 homolog (yeast) antibody; YOD1 OTU deubiquinating enzyme 1; S. cerevisiae; homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin thioesterase OTU1 protein (1-44AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，YOD1 Antibody (CSB-PA713352LA01HU)，的标记方式是Non-conjugated。对于YOD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA713352LB01HU YOD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA713352LC01HU YOD1 Antibody, FITC conjugated
    Biotin CSB-PA713352LD01HU YOD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.
  • 基因功能参考文献：
    1. This study showed that YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation. PMID: 30145984
    2. Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP/TAZ level. PMID: 28416659
    3. Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer. PMID: 28502290
    4. These data define that YOD1 antagonizes TRAF6/p62-dependent IL-1 signaling to NF-kappaB. PMID: 28244869
    5. Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response. PMID: 27753622
    6. activity of the p97-associated deubiquitinylase YOD1 is also required for substrate disposal PMID: 26463207
    7. miR-373 increases proliferation by directly targeting YOD1 in cervical cancer. PMID: 25747718
    8. The assignment of a p97-associated ubiquitin processing function to YOD1 adds to our understanding of p97's role in the dislocation of misfolded proteins from the endoplasmic reticulum. PMID: 19818707

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 25035

    OMIM: 612023

    KEGG: hsa:55432

    STRING: 9606.ENSP00000326813

    UniGene: Hs.567533