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ZBTB20 Antibody

  • 货号：
    CSB-PA867198ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA867198ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZBTB20 Polyclonal antibody
  • Uniprot No.：
    Q9HC78
  • 基因名：
    ZBTB20
  • 别名：
    Dendritic derived BTB/POZ zinc finger protein antibody; Dendritic-derived BTB/POZ zinc finger protein antibody; DKFZp566F123 antibody; DPZF antibody; HOF antibody; ODA 8S antibody; OTTHUMP00000215066 antibody; OTTHUMP00000215067 antibody; OTTHUMP00000215069 antibody; OTTHUMP00000215071 antibody; ZBT20_HUMAN antibody; Zbtb20 antibody; zinc finger 288 antibody; zinc finger and BTB domain containing 20 antibody; Zinc finger and BTB domain-containing protein 20 antibody; Zinc finger protein 288 antibody; ZNF288 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger and BTB domain-containing protein 20 protein (100-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
  • 基因功能参考文献：
    1. ZBTB20 knockdown inhibited glioblastoma cell proliferation, migration, and invasion. PMID: 30099442
    2. High ZBTB20 expression is associated with hepatocellular carcinoma. PMID: 26893361
    3. We report a boy with intellectual disability carrying two de novo missense mutations in the last exon of ZBTB20 (Ser616Phe and Gly741Arg; both previously unreported). One of them, Ser616Phe, affects an amino acid located in one of the C2H2 zing-fingers involved in DNA-binding and close to other missense mutations already described. Reverse phenotyping showed that this patient presents with classic features of Primrose syn PMID: 27061120
    4. ZBTB20 rs9841504 polymorphism is a protective factor for gastric cancer rather than esophageal cancer. PMID: 27646774
    5. 3q13.31 microdeletion-based dosage imbalance of ZBTB20 linked to a range of neurodevelopmental, cognitive and psychiatric disorders, likely mediated by dysregulation of multiple ZBTB20 target genes. PMID: 25062845
    6. Major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20. PMID: 24694013
    7. important role for ZBTB20 in controlling NSCLC development PMID: 25311537
    8. Missense mutations in ZBTB20 underlie Primrose syndrome. PMID: 25017102
    9. This study disclosed Zbtb20-mediated transcriptional repressor mechanism may be involved in development of the human archicortex. PMID: 23283686
    10. Polymorphism in ZBTB20 gene is associated with gastric cancer. PMID: 23861218
    11. We identified new susceptibility loci for non-cardia gastric cancer at 3q13.31: rs9841504 in ZBTB20 PMID: 22037551
    12. ZBTB20 mRNA & protein expression were elevated significantly in HCC tissues compared with the paired non-tumor tissues & normal liver. HCC recurrence or metastasis increased & disease-free survival decreased with high ZBTB20 expression. PMID: 21702992
    13. Misexpression of Zbtb20 in transgenic mice converts the normal cytoarchitectonic organization of the subiculum, postsubiculum, and granular retrosplenial cortex to a CA1-like stratum pyramidale. PMID: 19955470

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  • 相关疾病：
    Primrose syndrome (PRIMS)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.
  • 数据库链接：

    HGNC: 13503

    OMIM: 259050

    KEGG: hsa:26137

    STRING: 9606.ENSP00000419153

    UniGene: Hs.202577