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ZBTB7B Antibody

  • 货号：
    CSB-PA026344GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O15156
  • 基因名：
    ZBTB7B
  • 别名：
    c Krox antibody; cKrox antibody; DKFZp686G01254 antibody; hc Krox antibody; hcKrox antibody; Krueppel-related zinc finger protein cKrox antibody; Kruppel related zinc finger protein c Krox antibody; Kruppel related zinc finger protein cKrox antibody; Kruppel related zinc finger protein hcKrox antibody; T helper inducing POZ/Kruppel like factor antibody; T-helper-inducing POZ/Krueppel-like factor antibody; Th-POK antibody; ThPOK antibody; ZBT7B_HUMAN antibody; ZBTB 15 antibody; ZBTB 7B antibody; ZBTB15 antibody; ZBTB7B antibody; ZFP 67 antibody; Zfp-67 antibody; ZFP67 antibody; Zinc finger and BTB domain containing 15 antibody; Zinc finger and BTB domain containing 7B antibody; Zinc finger and BTB domain containing protein 15 antibody; Zinc finger and BTB domain containing protein 7B antibody; Zinc finger and BTB domain-containing protein 15 antibody; Zinc finger and BTB domain-containing protein 7B antibody; Zinc finger protein 67 homolog antibody; Zinc finger protein 857B antibody; Zinc finger protein Th POK antibody; Zinc finger protein Th-POK antibody; Zinc finger protein ThPOK antibody; ZNF857B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ZBTB7B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes.
  • 基因功能参考文献：
    1. ThPOK may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells. PMID: 23349906
    2. The distal regulatory element (DRE) in the Thpok gene also functions as a transcriptional enhancer, with DNA sequences specifically responsible for thymic enhancer activity. PMID: 23315079
    3. ThPOK transgene stably represses CD8 gene expression through the deacetylation of Cd8 loci in CD4 cell lineage commitment. PMID: 22730529
    4. The p65 subunit of NF-kappaB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3). PMID: 22139845
    5. comparing the promoter regions of the Th-POK gene between human and mouse, the region 3600 base pairs upstream from the transcription initiation site of the Th-POK gene was highly conserved PMID: 20847520
    6. impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis PMID: 20810990
    7. Thymoma neoplastic epithelial cells can induce Th-POK expression in T-cell subsets similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 expression in T-cell subsets between normal thymi and thymomas. PMID: 19886737
    8. These data suggest that the regulation of COL1A1 gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1, and Sp3. PMID: 17698844
    9. Chondroitin sulphate and its derived hydrolytic fragments (CSf) repress COL1A1 gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 transcription factors. PMID: 18298657
    10. Runx and ThPOK role in mechanisms of lineage-specific gene regulation in the process of T-cell commitments[review] PMID: 19479890

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 18668

    OMIM: 607646

    KEGG: hsa:51043

    STRING: 9606.ENSP00000292176

    UniGene: Hs.729279