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ZC3H14 Antibody

  • 货号：
    CSB-PA740793LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: ZC3H14 antibody at 3.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83, 66, 65, 81, 35, 33, 62, 67 kDa
      Observed band size: 83 kDa
    • IHC image of CSB-PA740793LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA740793LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZC3H14 Polyclonal antibody
  • Uniprot No.：
    Q6PJT7
  • 基因名：
    ZC3H14
  • 别名：
    FLJ11806 antibody; Mammalian suppressor of tau pathology-2 antibody; MGC26892 antibody; MSUT-2 antibody; Nuclear protein UKp68 antibody; NY REN 37 antibody; NYREN 37 antibody; Renal carcinoma antigen NY REN 37 antibody; Renal carcinoma antigen NY-REN-37 antibody; Renal carcinoma antigen NYREN 37 antibody; suppressor of tau 2, C. elegans, homolog of antibody; SUT2 antibody; UKp68 antibody; ZC3H14 antibody; ZC3HE_HUMAN antibody; Zinc finger CCCH domain-containing protein 14 antibody; Zinc finger CCCH type containing 14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger CCCH domain-containing protein 14 protein (176-306AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZC3H14 Antibody (CSB-PA740793LA01HU)，的标记方式是Non-conjugated。对于ZC3H14 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA740793LB01HU ZC3H14 Antibody, HRP conjugated ELISA
    FITC CSB-PA740793LC01HU ZC3H14 Antibody, FITC conjugated
    Biotin CSB-PA740793LD01HU ZC3H14 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
  • 基因功能参考文献：
    1. ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus. PMID: 27563065
    2. we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies PMID: 24671764
    3. report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein PMID: 21734151
    4. MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation. PMID: 21355046
    5. New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders. PMID: 20658987
    6. these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins PMID: 17630287
    7. multiple transcripts encoding several ZC3H14 isoforms exist in vivo PMID: 19303045

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  • 相关疾病：
    Mental retardation, autosomal recessive 56 (MRT56)
  • 亚细胞定位：
    Nucleus speckle.; [Isoform 1]: Nucleus speckle.; [Isoform 3]: Nucleus speckle.; [Isoform 6]: Cytoplasm.
  • 蛋白家族：
    ZC3H14 family
  • 组织特异性：
    Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.
  • 数据库链接：

    HGNC: 20509

    OMIM: 613279

    KEGG: hsa:79882

    STRING: 9606.ENSP00000251038

    UniGene: Hs.684046