Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ZFP57 Antibody

ZFP57 Antibody

  • 货号：
    CSB-PA865138LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, 293 whole cell lysate, Mouse brain tissue
      All lanes: ZFP57 antibody at 13.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52, 60, 62 kDa
      Observed band size: 52 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZFP57 Polyclonal antibody
  • Uniprot No.：
    Q9NU63
  • 基因名：
    ZFP57
  • 别名：
    ZFP57 antibody; C6orf40 antibody; ZNF698 antibody; Zinc finger protein 57 homolog antibody; Zfp-57 antibody; Zinc finger protein 698 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Zinc finger protein 57 homolog protein (183-295AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZFP57 Antibody (CSB-PA865138LA01HU)，的标记方式是Non-conjugated。对于ZFP57 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865138LB01HU ZFP57 Antibody, HRP conjugated ELISA
    FITC CSB-PA865138LC01HU ZFP57 Antibody, FITC conjugated
    Biotin CSB-PA865138LD01HU ZFP57 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
  • 基因功能参考文献：
    1. transient neonatal diabetes type 1 is associated with ZFP57 mutations PMID: 27075368
    2. ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth PMID: 24469060
    3. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
    4. These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1. PMID: 24193346
    5. Mouse and human ZFP57 are orthologs despite relatively low sequence identity. PMID: 24135613
    6. ZFP57 vZFP57 vZFP57 PMID: 23748067
    7. hZFP57 mutations and hypomethylation of the TNDM1 imprinted control region both associated with Transient Neonatal Diabetes Mellitus type 1 result in loss of hZFP57 binding to the TNDM1 locus. PMID: 23499433
    8. no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases PMID: 21863059
    9. this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS PMID: 19632365
    10. Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. PMID: 18622393
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445

    显示更多

    收起更多

  • 相关疾病：
    Transient neonatal diabetes mellitus 1 (TNDM1)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
  • 数据库链接：

    HGNC: 18791

    OMIM: 601410

    KEGG: hsa:346171

    UniGene: Hs.156326