Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ZFPM2 Antibody

ZFPM2 Antibody

  • 货号：
    CSB-PA855487DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA855487DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA855487DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZFPM2 Polyclonal antibody
  • Uniprot No.：
    Q8WW38
  • 基因名：
    ZFPM2
  • 别名：
    FOG-2 antibody; FOG2_HUMAN antibody; Friend of GATA 2 antibody; Friend of GATA protein 2 antibody; Friend of GATA2 antibody; hFOG-2 antibody; ZFPM2 antibody; Zinc finger protein 89B antibody; Zinc finger protein M2 antibody; Zinc finger protein multitype 2 antibody; Zinc finger protein ZFPM2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein ZFPM2 protein (982-1151AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 基因功能参考文献：
    1. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2. PMID: 29972125
    2. when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. PMID: 29018978
    3. Aberrant methylation status at the promoter CpG island shore of ZFPM2 gene may be associated with its gene transcription regulation in the tetralogy of fallot patients PMID: 26959486
    4. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. PMID: 28373160
    5. ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology. PMID: 26207917
    6. Isolated congenital diaphragmatic hernia was the predominant phenotype observed in our ZFPM2 mutation patients. PMID: 24702427
    7. screened a larger CTD population, which comprised 145 tetralogy of Fallot (TOF), 37 double-outlet ventricle outflow (DORV), and 18 transposition of the great artery (TGA), to investigate exon mutations as well as copy number variations in ZFPM2/FOG2 PMID: 25025186
    8. Whole exome sequencing identified independent missense mutations in FOG2 in two patients with 46,XY gonadal dysgenesis. PMID: 24549039
    9. Findings indicate that zinc finger protein, multitype 2 protein (ZFPM2) plays a role in diaphragm and cardiovascular development. PMID: 24769157
    10. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
    11. our results provide strong evidence regarding the susceptibility of the ZFPM2 gene to the development of non-syndromic TOF/DORV. PMID: 24469719
    12. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
    13. Variants of the ZFPM2/FOG2 gene might be a common cause of Double outlet right ventricle. PMID: 21919901
    14. Sex Cord Stromal Tumors in childhood exhibited an embryonal gonadal phenotype, expressing a FOG-2/GATA-4 pattern in keeping with embryonal gonads. PMID: 23029311
    15. association of the ZFPM2 SNP, rs12678719, with antipsychotic-induced parkinsonism PMID: 21947317
    16. New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle PMID: 20807224
    17. These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation. PMID: 20705609
    18. FOG-2 has specific role in fetal ovaries counteracting transactivation of mullerian-inhibiting substance gene by GATA-4. Important role for FOG-2 and GATA transcription factors in developing ovary. PMID: 12606418
    19. AML1-FOG2 and FOG2-AML1 are expressed in myelodysplastic syndrome; results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of AML1 and GATA developmental programs in the disease pathogenesis PMID: 15705784
    20. FOG-2 affects not only cardiac development but also gonadal function and its preservation PMID: 17309641
    21. sequence variation in diaphragmatic hernia PMID: 17568391
    22. SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling PMID: 18658259
    23. Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively; USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. PMID: 20005803

    显示更多

    收起更多

  • 相关疾病：
    Tetralogy of Fallot (TOF); Diaphragmatic hernia 3 (DIH3); 46,XY sex reversal 9 (SRXY9); Conotruncal heart malformations (CTHM)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FOG (Friend of GATA) family
  • 组织特异性：
    Widely expressed at low level.
  • 数据库链接：

    HGNC: 16700

    OMIM: 187500

    KEGG: hsa:23414

    STRING: 9606.ENSP00000384179

    UniGene: Hs.431009