ZFX Antibody

1. MiR-493 functioned as tumor suppressor in HCC cells by regulating ZFX expression. Thus, miR-493 may provide potential value for HCC treatment. PMID: 29758928
2. The depletion of ZFX using lentiviral shRNAs significantly inhibited cell proliferation by inducing cell cycle arrest in G0/G1 phase and resulted in increased cell apoptosis and invasive repression. PMID: 30007968
3. The research findings indicate that Zinc finger protein X-linked (ZFX) activates and maintains EpCAM(+) liver cancer stem cells by promoting nuclear translocation and transactivation of beta-catenin. Furthermore, combination of ZFX and epithelial cell adhesion molecule (EpCAM) may serve as a significant indicator for prognosis of patients with hepatocellular carcinoma. PMID: 28156061
4. Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. PMID: 26967242
5. colon cancer-associated transcript-1 knockdown inhibits proliferation and invasion of laryngeal squamous cell cancer cells through enhancing zinc finger protein, X-linked by sponging microRNA-218, elucidating a novel colon cancer-associated transcript-1-microRNA-218-zinc finger protein, X-linked regulatory axis in laryngeal squamous cell cancer and providing a promising therapeutic target for laryngeal cancer PMID: 28631575
6. EZH2 and ZFX genes do not seem to have an impact on the onset of most parathyroid tumours, both benign and malignant, though further studies on larger cohorts of different ethnicity are needed. PMID: 26876532
7. Zinc finger and X-linked factor ZFX transactivates the SET transcript 2 promoter through binding to a site closely located to the transcription start site. PMID: 27775603
8. miR-144 has been demonstrated to act as a tumour suppressor in hepatocellular carcinoma (HCC) cell growth and motility by directly targeting ZFX, which implicates its potential applications in the development of HCC treatment PMID: 28229969
9. demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukemic cells partially via B4GALT1, which suggests that ZFX is a new regulator of leukemic cells and warrants intensive investigations on this 'stemness' regulator in these deadly diseases PMID: 27797721
10. ZFX is a novel oncogene promoting cell proliferation and inducing imatinib resistance via PI3K/Akt signaling pathway PMID: 26912059
11. Zinc finger protein x-linked contributes to patient prognosis, and regulates cell proliferation and apoptosis in human laryngeal squamous cell carcinoma. PMID: 26823701
12. ZFX expression may have a role in poor prognosis of renal cell carcinoma patients PMID: 26540164
13. Nasopharyngeal carcinoma patients with high ZFX expression had lower 5-year overall survival rates, progression-free survival rates, loco-regional relapse-free survival rates and distant metastasis-free survival rates than those with low ZFX expression PMID: 26097576
14. Our results provide evidence suggesting that ZFX overexpression is associated with the development of tongue SCC and ZFX knockdown is a potential treatment for tumor suppression PMID: 25916205
15. These data demonstrate that ZFX functions as a critical upstream regulator of c-Myc and plays essential roles in the maintenance of the glioma stem cells phenotype PMID: 24831540
16. ZFX is essential for the development and progression of squamous cell carcinoma of the tongue. PMID: 25355536
17. our findings for the first time demonstrated that ZFX expression may be associated with the progress of colorectal cancer PMID: 25031734
18. Study detected the expression of ZFX in 42 patients with renal cancer and found the expression of ZFX was specifically upregulated in cancer tissues at the mRNA and protein levels. PMID: 25441684
19. Expression of ZFX promotes tumor growth in hepatocellular carcinoma. PMID: 24585547
20. ZFX knockdown prevented tumor cell growth and migration in vitro and decreased proportion of tumor bearing mice and reduced mean tumor volume in a subcutaneous tumor model. PMID: 24228108
21. ZFX is over-expressed in children with B-acute lymphoblastic leukemia and its levels are higher in those with a poor prognosis than those with a good prognosis PMID: 23866268
22. Zinc finger X-chromosomal protein promoted the growth and migration of gallbladder cancer cells. PMID: 23860324
23. ZFX plays a prominent role in gastric cancer tumorigenicity and may have potential applications in the diagnosis or treatment of GC. PMID: 23587796
24. This study demonistrated that ZFX regulates glioma cell proliferation and survival. PMID: 23322077
25. ZFX may play an important role in cell growth control and cell cycle progression of 95D cells. PMID: 23461064
26. ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in human Embryonic stem cells. PMID: 22879936
27. disseminated gastric cancer cells could survive in bone marrow when low expression of miR-144 permits upregulation of ZFX. This may play a key role in the progression of gastric cancer. PMID: 22955854
28. Zfx may play a critical role in cell proliferation, cell cycle distribution, and apoptosis of human malignant glioma cells. PMID: 22185393
29. ZFX was differentially expressed in different tumour types and grades of gastric cancer. PMID: 22357206
30. high expression of ZFX is associated with laryngeal squamous cell carcinoma progression and knockdown of ZFX may block tumor cell growth mainly by promoting cell apoptosis PMID: 22009483

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HGNC: 12869

OMIM: 314980

KEGG: hsa:7543

STRING: 9606.ENSP00000304985

UniGene: Hs.336681