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ZFYVE16 Antibody

  • 货号：
    CSB-PA800100ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA800100ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA800100ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA800100ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZFYVE16 Polyclonal antibody
  • Uniprot No.：
    Q7Z3T8
  • 基因名：
  • 别名：
    AI035632 antibody; B130024H06Rik antibody; B130031L15 antibody; DKFZp686E13162 antibody; Endofin antibody; Endosomal associated FYVE domain protein antibody; Endosome associated FYVE domain protein antibody; Endosome-associated FYVE domain protein antibody; KIAA0305 antibody; KIAA0305; antibody; mKIAA0305 antibody; OTTMUSP00000029589 antibody; RGD1564784 antibody; ZFY16_HUMAN antibody; ZFYVE16 antibody; Zinc finger FYVE domain containing protein 16 antibody; Zinc finger FYVE domain-containing protein 16 antibody; Zinc finger; FYVE domain containing 16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger FYVE domain-containing protein 16 protein (1-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
  • 基因功能参考文献：
    1. Two SNPs located near the ZFYVE16 gene on chromosome 5 may have played a role in the early, multicompartment sacrocolpopexy failure. PMID: 26944198
    2. Disruption of proper localization to the endosomes and the Y515 phosphorylation of Endofin enhanced MAPK activation suggesting that Endofin negatively modulates EGFR signaling following receptor endocytosis. PMID: 19887107
    3. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
    4. The key mode of action of Trx-SARA was to reduce the level of Smad2 and Smad3 in complex with Smad4 after TGF-beta1 stimulation. PMID: 16775010
    5. Facilitates TGF-beta signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing Smad4 to the proximity of the receptor complex. PMID: 17272273
    6. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516

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  • 亚细胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
  • 组织特异性：
    Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 20756

    OMIM: 608880

    KEGG: hsa:9765

    STRING: 9606.ENSP00000337159

    UniGene: Hs.482660