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ZHX2 Antibody

  • 货号：
    CSB-PA008272
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6X8
  • 基因名：
    ZHX2
  • 别名：
    AFP regulator 1 antibody; AFR1 antibody; Alpha fetoprotein regulator 1 antibody; Alpha-fetoprotein regulator 1 antibody; KIAA0854 antibody; RAF antibody; Regulator of AFP antibody; Transcription factor ZHX2 antibody; ZHX2 antibody; ZHX2_HUMAN antibody; Zinc finger and homeodomain protein 2 antibody; Zinc fingers and homeoboxes 2 antibody; Zinc fingers and homeoboxes protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ZHX2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
  • 基因功能参考文献：
    1. These studies reveal ZHX2 as a potential therapeutic target for clear cell renal cell carcinoma. PMID: 30026228
    2. ZHX2 expression in renal cell carcinoma PMID: 28152006
    3. Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes PMID: 28258223
    4. These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs. PMID: 26679602
    5. Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription. PMID: 25473899
    6. Data indicate that zinc-fingers and homeoboxes 2 (ZHX2) suppresses glypican 3 (GPC3) transcription by binding with its core promoter. PMID: 25195714
    7. Two novel markers, rs7840785 (PINX1) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness. PMID: 25746325
    8. simultaneous application of ZFN and rescue DNA induced gene repair of the disease-causing mutation on the genomic level, resulting in recovery of protein expression. PMID: 22661463
    9. Expression of a constitutively active Raf transgene enhances lymphoproliferation, indicating a role for the Ras-MAPK pathway in linker for activation of T cells (LAT)-mediated autoimmune hyperproliferation. PMID: 22984075
    10. There was no significant difference in high and low percentage of HbF in GG, GA, and AA bearing individuals showing that ZHX2 gene variant has no role in ameliorating the severity of beta-thalassemia major in the South Indian population from Andhra Pradesh. PMID: 21443521
    11. results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines PMID: 22078940
    12. Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2. PMID: 21987443
    13. identification as a transcriptional repressor PMID: 12741956
    14. ZHX2, a transcriptional repressor, may participate in globin gene regulation. PMID: 16952470
    15. High ZHX2 is associated with metastasis in hepatocellular carcinoma. PMID: 17447851
    16. These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer. PMID: 18194454

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ZHX family
  • 组织特异性：
    Ubiquitously expressed. Expressed in podocytes.
  • 数据库链接：

    HGNC: 18513

    OMIM: 609185

    KEGG: hsa:22882

    STRING: 9606.ENSP00000314709

    UniGene: Hs.377090