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ZMIZ1 Antibody

  • 货号：
    CSB-PA890749LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA890749LA01HU diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA890749LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZMIZ1 Polyclonal antibody
  • Uniprot No.：
    Q9ULJ6
  • 基因名：
    ZMIZ1
  • 别名：
    hZIMP10 antibody; KIAA1224 antibody; MIZ antibody; PIAS like protein hZimp10 antibody; PIAS like protein on chromosome 10 antibody; PIAS like protein Zimp10 antibody; PIAS-like protein Zimp10 antibody; RAI 17 antibody; Retinoic acid induced 17 antibody; Retinoic acid induced protein 17 antibody; Retinoic acid-induced protein 17 antibody; TRAFIP10 antibody; Zimp10 antibody; Zinc finger containing Miz1 PIAS like protein on chromosome 10 antibody; Zinc finger MIZ domain-containing protein 1 antibody; Zinc finger MIZ-type containing 1 antibody; Zmiz1 antibody; ZMIZ1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger MIZ domain-containing protein 1 protein (405-559AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZMIZ1 Antibody (CSB-PA890749LA01HU)，的标记方式是Non-conjugated。对于ZMIZ1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA890749LB01HU ZMIZ1 Antibody, HRP conjugated ELISA
    FITC CSB-PA890749LC01HU ZMIZ1 Antibody, FITC conjugated
    Biotin CSB-PA890749LD01HU ZMIZ1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex.
  • 基因功能参考文献：
    1. In a two-stage genome-wide association study and subsequent replication study to identify genetic factors associated with primary dysmenorrhoea in Chinese women, analysis provided evidence of a significant (P<5 x 10(-8)) association at rs76518691 in the gene ZMIZ1 and at rs7523831 near NGF. PMID: 28447608
    2. we have identified a molecular phenotype of MS defined by expression of the MS risk gene ZMIZ1 in blood, and by other genes, especially transcription factors. ZMIZ1 expression is affected by, and interacts with, the environmental risk factors EBV and Vitamin D. PMID: 28063629
    3. rs1250569 (ZMIZ1) and rs10114470 (TL1A) are two novel loci that indicate susceptibility to Inflammatory Bowel Disease in Han-Chinese patients. PMID: 28456797
    4. This case represents the first constitutional balanced translocation disrupting and fusing both MIZ-type containing and proline-rich 12 and provides clues for the potential function and effects of these in the central nervous system. PMID: 26163108
    5. At the ZMIZ1 locus, we show that perturbation of ZMIZ1 expression in human islets and beta-cells influences exocytosis and insulin secretion, highlighting a novel role for ZMIZ1 in the maintenance of glucose homeostasis. PMID: 26624892
    6. Targeting the NOTCH1-ZMIZ1 interaction might combat leukemic growth. PMID: 26522984
    7. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
    8. ZMIZ1 is a susceptibility gene for vitiligo in Chinese population. PMID: 24667117
    9. ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human squamous cell carcinomas, suggesting that ZMIZ1 may play a broader role in epithelial cancers. PMID: 23426136
    10. ZMIZ1 and activated NOTCH1 are coexpressed in a subset of human T-ALL patients and cell lines. PMID: 23161489
    11. First line of evidence demonstrates a physiological role for endogenous Zimp10 in regulating Smad3/4-mediated transcription. PMID: 16777850
    12. (RAI17) was found to be upregulated in WT-Add1 vs MUT-Add1 overexpressing cells, possibly representing a key molecule/axis for the functional Add1-induced effect PMID: 17512505
    13. Expression of exogenous hZimp10 enhances the transcriptional activity of p53 and knockdown of endogenous hZimp10 reduces the transcriptional activity of p53. PMID: 17584785
    14. provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis PMID: 17967885
    15. Fusion of ZMIZ1 to ABL1 is associated with a B-cell acute lymphoblastic leukemia with a t(9;10)(q34;q22.3) translocation PMID: 18007576

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Cytoplasm. Nucleus.
  • 组织特异性：
    Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 16493

    OMIM: 607159

    KEGG: hsa:57178

    STRING: 9606.ENSP00000334474

    UniGene: Hs.193118