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ZNF131 Antibody

  • 货号：
    CSB-PA026530LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026530LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA026530LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZNF131 Polyclonal antibody
  • Uniprot No.：
    P52739
  • 基因名：
    ZNF131
  • 别名：
    ZNF131Zinc finger protein 131 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 131 protein (80-379AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZNF131 Antibody (CSB-PA026530LA01HU)，的标记方式是Non-conjugated。对于ZNF131 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA026530LB01HU ZNF131 Antibody, HRP conjugated ELISA
    FITC CSB-PA026530LC01HU ZNF131 Antibody, FITC conjugated
    Biotin CSB-PA026530LD01HU ZNF131 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
  • 基因功能参考文献：
    1. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability. PMID: 28596487
    2. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters. PMID: 26841866
    3. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131 PMID: 23404503
    4. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor. PMID: 23159625
    5. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation. PMID: 22467880
    6. The mechanism of Znf131 nuclear localization, is reported. PMID: 17306895
    7. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1. PMID: 18847501

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  • 亚细胞定位：
    Nucleus. Note=Sumoylation does not affect nuclear localization.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.
  • 数据库链接：

    HGNC: 12915

    OMIM: 604073

    KEGG: hsa:7690

    UniGene: Hs.535804