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ZNF24 Antibody

  • 货号：
    CSB-PA003108
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using KOX17 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P17028
  • 基因名：
    ZNF24
  • 别名：
    KOX17 antibody; Retinoic acid suppression protein A antibody; RSG A antibody; RSG-A antibody; RSGA antibody; Zfp191 antibody; Zinc finger and SCAN domain containing protein 3 antibody; Zinc finger and SCAN domain-containing protein 3 antibody; Zinc finger protein 191 antibody; Zinc finger protein 24 antibody; Zinc finger protein KOX17 antibody; ZNF 24 antibody; ZNF191 antibody; ZNF24 antibody; ZNF24_HUMAN antibody; ZSCAN 3 antibody; ZSCAN3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human KOX17.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.
  • 基因功能参考文献：
    1. miR-940 promoted gastric cancer progression by directly downregulating ZNF24 expression. PMID: 26317898
    2. In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks. PMID: 25550468
    3. results suggest that consecutive ZF1-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function. PMID: 24224020
    4. ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z. PMID: 22678762
    5. ZNF191 can directly bind to the CTNNB1 promoter and activate the expression of beta-catenin and its downstream target genes such as cyclin D1 in hepatoma cell lines. PMID: 22213192
    6. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription. PMID: 20510677
    7. Overexpression and purification of single zinc finger peptides of ZNF191 were performed. PMID: 17270462
    8. ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development, and tumor growth. PMID: 19463170
    9. Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage. PMID: 19544452

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in many tissues except in heart.
  • 数据库链接：

    HGNC: 13032

    OMIM: 194534

    KEGG: hsa:7572

    STRING: 9606.ENSP00000261332

    UniGene: Hs.514802