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ZNF268 Antibody

  • 货号：
    CSB-PA026625LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, K562 whole cell lysate
      All lanes: ZNF268 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 109, 90, 10, 12, 16, 6, 13 kDa
      Observed band size: 109 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA026625LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZNF268 Polyclonal antibody
  • Uniprot No.：
    Q14587
  • 基因名：
    ZNF268
  • 别名：
    ZNF268Zinc finger protein 268 antibody; Zinc finger protein HZF3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 268 protein (416-603AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZNF268 Antibody (CSB-PA026625LA01HU)，的标记方式是Non-conjugated。对于ZNF268 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA026625LB01HU ZNF268 Antibody, HRP conjugated ELISA
    FITC CSB-PA026625LC01HU ZNF268 Antibody, FITC conjugated
    Biotin CSB-PA026625LD01HU ZNF268 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
  • 基因功能参考文献：
    1. The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. PMID: 23665872
    2. These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. PMID: 23091055
    3. ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
    4. This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. PMID: 12822888
    5. ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism PMID: 15547661
    6. 4 alternative transcripts of ZNF268 were detected in the human blood cells. PMID: 16735226
    7. ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity PMID: 16787922
    8. ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. PMID: 16865230
    9. HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding PMID: 18375384
    10. results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. PMID: 18677094
    11. Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. PMID: 18774934
    12. aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. PMID: 18949428

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  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform
  • 数据库链接：

    HGNC: 13061

    OMIM: 604753

    KEGG: hsa:10795

    STRING: 9606.ENSP00000228289

    UniGene: Hs.124047