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ZNF462 Antibody

  • 货号：
    CSB-PA026768LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA026768LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA026768LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZNF462 Polyclonal antibody
  • Uniprot No.：
    Q96JM2
  • 基因名：
    ZNF462
  • 别名：
    DKFZp686B2325 antibody; DKFZp762N2316 antibody; FLJ14960 antibody; FLJ45904 antibody; KIAA1803 antibody; RP11-508N12.1 antibody; Zinc finger protein 462 antibody; ZN462_HUMAN antibody; ZNF462 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 462 protein (2223-2506AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ZNF462 Antibody (CSB-PA026768LA01HU)，的标记方式是Non-conjugated。对于ZNF462 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA026768LB01HU ZNF462 Antibody, HRP conjugated ELISA
    FITC CSB-PA026768LC01HU ZNF462 Antibody, FITC conjugated
    Biotin CSB-PA026768LD01HU ZNF462 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation.
  • 基因功能参考文献：
    1. In the current study we describe a patient with a syndromic form of autism spectrum disorder and intellectual disability characterized by metopic craniosynostosis, ptosis and corpus callosum dysgenesis most likely caused by ZNF462 haploinsufficiency. The possible contribution of the disruption of KLF12 by one of the translocation breakpoints remains unclear. PMID: 29427787
    2. Loss of function variants in ZNF462 were identified in patients with ptosis, metopic ridging, craniosynostosis, dysgenesis of the corpus callosum, and developmental delay. PMID: 28513610
    3. Zinc finger protein 462 (ZNF462) is the first human O-GlcNAc-6-phosphate modified protein. PMID: 22826440
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 21684

    OMIM: 617371

    KEGG: hsa:58499

    STRING: 9606.ENSP00000277225

    UniGene: Hs.370379