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ZNF750 Antibody

  • 货号：
    CSB-PA027012GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q32MQ0
  • 基因名：
    ZNF750
  • 别名：
    ZNF750 antibody; Zinc finger protein 750 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human ZNF750
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.
  • 基因功能参考文献：
    1. ZNF750 acts as a potential tumor suppressor gene, and regulates tumor microenvironment. PMID: 29890464
    2. The low expression of ZNF750 was significantly associated with a poor prognosis. PMID: 29216641
    3. ZNF750 expression predicts sensitivity to CRT and can be a biomarker that reliably predicts the response of ESCC to CRT. PMID: 28558382
    4. ZNF750 Mutation is associated with esophageal squamous cell carcinoma. PMID: 27749841
    5. Suggest no connection of ZNF750 variants with psoriasis or its subphenotypes. PMID: 24005976
    6. ZNF750 thus controls differentiation in concert with RCOR1 and CTBP1/2 by acting with either KDM1A to repress progenitor genes or KLF4 to induce differentiation genes. PMID: 25228645
    7. ZNF750 was specifically expressed in the epidermal suprabasal layers and its expression was augmented during differentiation, both in human skin and in-vitro, peaking in the granular layer. PMID: 22936986
    8. ZNF750 directly links a tissue-specifying factor, p63, to an effector of terminal differentiation, KLF4. PMID: 22364861
    9. Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis. PMID: 22185198
    10. ZNF750 mutations could contribute to psoriasis susceptibility. PMID: 18256691

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  • 相关疾病：
    Seborrhea-like dermatitis with psoriasiform elements (SLDP)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.
  • 数据库链接：

    HGNC: 25843

    OMIM: 610226

    KEGG: hsa:79755

    STRING: 9606.ENSP00000269394

    UniGene: Hs.464391