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ZP4 Antibody

  • 货号：
    CSB-PA040107
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q12836
  • 基因名：
    ZP4
  • 别名：
    Processed zona pellucida sperm-binding protein 4 antibody; ZBP antibody; Zona pellucida B protein antibody; Zona pellucida glycoprotein 4 antibody; Zona pellucida protein B antibody; Zona pellucida sperm binding protein 4 antibody; Zp-4 antibody; ZP1 antibody; ZP4 antibody; ZP4_HUMAN antibody; ZPB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZP4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
  • 基因功能参考文献：
    1. ZO4 is highly expressed in ovarian tissue in PCOS patients with regular cycle and without hyperandrogenism; in some patients with PCOS and infertility, ZP4 mutation can be found. PMID: 25740067
    2. Human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice; other zona proteins may be needed for human gamete recognition. PMID: 21173071
    3. ZPB induces acrosomal exocytosis through a Gi independent pathway. PMID: 15805145
    4. Binding sites for recombinant zona pellucida B (ZPB) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
    5. Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
    6. induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
    7. a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505

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  • 亚细胞定位：
    [Processed zona pellucida sperm-binding protein 4]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPB subfamily
  • 组织特异性：
    Expressed in oocytes.
  • 数据库链接：

    HGNC: 15770

    OMIM: 613514

    KEGG: hsa:57829

    STRING: 9606.ENSP00000355529

    UniGene: Hs.136241