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cagA Antibody

  • 货号：
    CSB-PA14367A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Helicobacter pylori cagA Polyclonal antibody
  • Uniprot No.：
    P55980
  • 基因名：
    cagA
  • 别名：
    cagA antibody; cag26 antibody; cai antibody; HP_0547Cytotoxicity-associated immunodominant antigen antibody; 120 kDa protein antibody; CAG pathogenicity island protein 26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Helicobacter pylori
  • 免疫原：
    Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen protein (1-294AA)
  • 免疫原种属：
    Helicobacter pylori
  • 标记方式：
    Non-conjugated

    本页面中的产品，cagA Antibody (CSB-PA14367A0Rb)，的标记方式是Non-conjugated。对于cagA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA14367B0Rb cagA Antibody, HRP conjugated ELISA
    FITC CSB-PA14367C0Rb cagA Antibody, FITC conjugated
    Biotin CSB-PA14367D0Rb cagA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be necessary for the transcription, folding, export, or function of the cytotoxin.
  • 基因功能参考文献：
    1. The s conclude that CagQ is a membrane protein in a type IV secretion system and is crucial for maintaining CagA expression and CagA-induced apoptotic effects. PMID: 29306012
    2. The vacuolating cytotoxin autotransporter (vacA) c1 genotype, but not cytotoxicity-associated immunodominant antigen (cagA) status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk. PMID: 29036792
    3. In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the s found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. PMID: 27445265
    4. Helicobacter pylori expressing cagA and vacA genes is prevalent in dyspeptic Ghanaian patients. PMID: 28655347
    5. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells. PMID: 28082808
    6. Data indicate that treatment of gastric epithelial cells with simvastatin reduced the level of cellular cholesterol and led to attenuation of translocation and phosphorylation of cytotoxin-associated gene A (CagA). PMID: 26730715
    7. Studies suggest that cytotoxin-associated gene A (CagA)-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. PMID: 26390415
    8. CagT plays an important role in the translocation of CagA into host epithelial cells. PMID: 23075784
    9. CagA upregulated CIP2A expression and this upregulation effect was dependent on Src and Ras/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways. PMID: 19959630
    10. In a stomach adenocarcinoma cell line, an increase in this protein correlated with the amount of the phosphorylated protein. PMID: 16278423
    11. These data demonstrate that VacA can downregulate CagA's effects on epithelial cells, a novel molecular mechanism showing how H. pylori can avoid excessive cellular damage. PMID: 19046339

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  • 数据库链接：

    KEGG: heo:C694_02825

    STRING: 85962.HP0547