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cyp125 Antibody

  • 货号：
    CSB-PA351308HA01MVZ
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mycobacterium tuberculosis cyp125 Polyclonal antibody
  • Uniprot No.：
    P9WPP1
  • 基因名：
    cyp125
  • 别名：
    cyp125 antibody; cyp125A1 antibody; Rv3545c antibody; MTCY03C7.11Steroid C26-monooxygenase antibody; EC 1.14.15.29 antibody; Cholest-4-en-3-one 26-monooxygenase antibody; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] antibody; Cholesterol C26-monooxygenase antibody; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] antibody; Cytochrome P450 125 antibody; Steroid C27-monooxygenase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mycobacterium tuberculosis
  • 免疫原：
    Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA)
  • 免疫原种属：
    Mycobacterium tuberculosis
  • 标记方式：
    Non-conjugated

    本页面中的产品，cyp125 Antibody (CSB-PA351308HA01MVZ)，的标记方式是Non-conjugated。对于cyp125 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA351308HB01MVZ cyp125 Antibody, HRP conjugated ELISA
    FITC CSB-PA351308HC01MVZ cyp125 Antibody, FITC conjugated
    Biotin CSB-PA351308HD01MVZ cyp125 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
  • 基因功能参考文献：
    1. M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation PMID: 26197389
    2. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. PMID: 25591012
    3. CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one. PMID: 20545858
    4. Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable. PMID: 19146393
    5. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. PMID: 19846551
    6. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. PMID: 19846552

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  • 蛋白家族：
    Cytochrome P450 family
  • 数据库链接：

    KEGG: mtu:Rv3545c

    STRING: 83332.Rv3545c