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cyp26b1 Antibody

  • 货号：
    CSB-PA721935LA01DIL
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: cyp26b1 antibody at 4.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46 kDa
      Observed band size: 51 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) cyp26b1 Polyclonal antibody
  • Uniprot No.：
    Q6EIG3
  • 基因名：
    cyp26b1
  • 别名：
    cyp26b1Cytochrome P450 26B1 antibody; Cyp26B1 antibody; EC 1.14.13.- antibody; Retinoic acid-metabolizing cytochrome antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish Cytochrome P450 26B1 protein (366-511AA)
  • 免疫原种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 标记方式：
    Non-conjugated

    本页面中的产品，cyp26b1 Antibody (CSB-PA721935LA01DIL)，的标记方式是Non-conjugated。对于cyp26b1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA721935LB01DIL cyp26b1 Antibody, HRP conjugated ELISA
    FITC CSB-PA721935LC01DIL cyp26b1 Antibody, FITC conjugated
    Biotin CSB-PA721935LD01DIL cyp26b1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.
  • 基因功能参考文献：
    1. we find that Cyp26 function is required in a short time window that overlaps the dynamic window of tenoblast condensation. However, cyp26b1 expression is largely restricted to regions between tenoblast condensations during this time PMID: 29227993
    2. The data demonstrate that RA-induced osteoblast-preosteocyte transitioning has multiple effects on developing bone in Cyp26b1 mutants, ranging from gain to loss of bone, depending on the allelic strength, the developmental stage and the cellular context. PMID: 26903503
    3. cyp26b1 is involved in limiting the activity of retinoic acid. Zygotic cyp26b1 was localized to presumptive rhombomere 3 and rhombomere 4 at early two-somite (2S) stage. Expression expands anteriorly to include rhombomere 2 at the 10S stage. PMID: 15661642
    4. effects of the inhibitor rather than excess retinoic acid most closely phenocopied the jaw defects seen with the Cyp26B1 morpholino PMID: 17616924
    5. Cyp26b1 is expressed within osteoblast cells, demonstrating that retinoic acid levels within these cells need to be tightly controlled PMID: 18927155
    6. cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly PMID: 18927157

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 数据库链接：

    KEGG: dre:324188

    STRING: 7955.ENSDARP00000101543

    UniGene: Dr.76359