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ftz-f1 Antibody

  • 货号：
    CSB-PA339334XA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: ftz-f1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P33244
  • 基因名：
    ftz-f1
  • 别名：
    Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha) (Nuclear receptor subfamily 5 group A member 3) ftz-f1 NR5A3 CG4059
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) ftz-f1 protein (790-1027aa )
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
  • 基因功能参考文献：
    1. the alpha6 helix is dynamic in solution when Ftz-F1 is bound to the LxxLL motif of its cofactor Ftz, undergoing motions on the fast (picosecond to nanosecond) as well as slow (microsecond to millisecond) time scales. PMID: 29547262
    2. a novel ecdysone-dependent enhancer in the intron of ftz-f1 gene PMID: 28726107
    3. Comparative analysis of enhancers containing Ftz/Ftz-F1 binding sites that were or were not bona fide targets in vivo suggested that GAF negatively regulates enhancers that contain Ftz/Ftz-F1 binding sites but are not actually utilized. PMID: 27723822
    4. dATAC histone acetyltransferase complex is indispensable for the regulation of expression and probably for the stabilization of Ftz-F1, the main transcription regulator of Halloween genes. PMID: 25959239
    5. betaFTZ-F1 is expressed in most cells at the late pupal stage, under the control of ecdysteroids and plays important roles during pupal development. PMID: 24611773
    6. functional equivalence of ftz-f1 orthologs in these sensitive in vivo assays argues against specific activating ligands for NR5A family members PMID: 23340581
    7. ssFTZ-F1 is required for fat-body remodeling in Drosophila PMID: 21978772
    8. betaFTZ-F1 is a regulator for temporal gene expression at the onset of metamorphosis PMID: 12392575
    9. betaFTZ-F1 plays a role in regulating ecdysteroid titers during post-embryonic developmentby regulating Phantom protein and Disembodied protein expression. PMID: 15936331
    10. EDG84A gene encoding pupal cuticle protein is one of the targets of ecdysteroid-inducible transcription factor betaFTZ-F1; betaFTZ-F1 is expressed in almost all tissues. PMID: 16025347
    11. Serves as a molecular sign to guide the recruitment of ecdysone receptor/Ultraspiracle/FISC to 20-hydroxyecdysone-inducible target promoters. PMID: 17015464
    12. propose that pair-rule genes, exemplified by Ftz/Ftz-F1, promote segmentation by acting at different hierarchical levels, regulating segmentation and regulatory genes PMID: 19679121
    13. The Ftz-F1 DNA binding domain interacts strongly with Ftz and dramatically facilitates the binding of Ftz to target DNA. PMID: 11520662

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR5 subfamily
  • 组织特异性：
    Expression in the parasegmental primordia of the embryonic blastoderm.
  • 数据库链接：

    KEGG: dme:Dmel_CG4059

    STRING: 7227.FBpp0074853

    UniGene: Dm.995