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lpxC Antibody

  • 货号：
    CSB-PA358910HA01ENV
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品描述：
    lpxC polyclonal antibody CSB-PA358910HA01ENV was produced in the rabbit immunized by using the Recombinant Escherichia coli UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase protein (1-305AA) as the immunogen. The target protein lpxC plays a critical role in catalyzing the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Due to its important role in lipid A synthesis, LpxC is an attractive target for the development of new antibacterial agents to treat Gram-negative infections.
    This Rabbit anti-Escherichia coli (strain K12) lpxC Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the lpxC proteins of Escherichia coli-origin and may be used to detect the endogenous levels of lpxC protein.
  • 产品名称：
    Rabbit anti-Escherichia coli lpxC Polyclonal antibody
  • Uniprot No.：
    P0A725
  • 基因名：
    lpxC
  • 别名：
    lpxC antibody; asmB antibody; envA antibody; b0096 antibody; JW0094 antibody; UDP-3-O-acyl-N-acetylglucosamine deacetylase antibody; UDP-3-O-acyl-GlcNAc deacetylase antibody; EC 3.5.1.108 antibody; Protein EnvA antibody; UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Escherichia coli
  • 免疫原：
    Recombinant Escherichia coli UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase protein (1-305AA)
  • 免疫原种属：
    Escherichia coli
  • 标记方式：
    Non-conjugated

    本页面中的产品，lpxC Antibody (CSB-PA358910HA01ENV)，的标记方式是Non-conjugated。对于lpxC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA358910HB01ENV lpxC Antibody, HRP conjugated ELISA
    FITC CSB-PA358910HC01ENV lpxC Antibody, FITC conjugated
    Biotin CSB-PA358910HD01ENV lpxC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    NaCl+NaN3
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

问答及客户评论

■ 客户评论
  • Western blot review for CD146 Monoclonal Antibody
    Tested application: WB, IP
    Test sample&species: E.coli
    Primary antibody dilution ratio: 1:1000
    Review: The experimental results are OK, but there are bands, which may be related to polyclonal antibodies. Also used for IP, although the manual is only ELISA.

靶点详情

  • 功能：
    Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
  • 基因功能参考文献：
    1. analysis of mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis PMID: 23316051
    2. the active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions PMID: 20709752
    3. The C-terminus of LpxC contains a signal sequence necessary for FtsH-dependent degradation. PMID: 16420369
    4. potency of LpxC inhibitors in vitro can be altered by assay conditions and development of inhibitorsand that the metal ion status of LpxC in vivo may influence the effectiveness of LpxC inhibitors as antibiotics. PMID: 17144651
    5. Functions of LpxC active site residues have been classified on the basis of changes in steady-state turnover and product binding affinity; side chains are identified that enhance and destabilize product affinity as well as enhance catalytic efficiency. PMID: 17176046
    6. A C-terminal tail of about 20 amino acids length is required for proteolysis of LpxC by FtsH PMID: 17651755

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  • 蛋白家族：
    LpxC family
  • 数据库链接：

    KEGG: ecj:JW0094

    STRING: 316385.ECDH10B_0078