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oxyR Antibody

  • 货号：
    CSB-PA364842XA11ENV
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: oxyR Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36 kDa
      Observed band size: 36 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P0ACQ4
  • 基因名：
    oxyR
  • 别名：
    Hydrogen peroxide-inducible genes activator (Morphology and auto-aggregation control protein), oxyR, momR mor
  • 反应种属：
    E.coli
  • 免疫原：
    Recombinant E.coli oxyR protein (1-94aa)
  • 免疫原种属：
    Escherichia coli(strain K12)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Affinity-chromatography
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability.
  • 基因功能参考文献：
    1. Constitutive expression of the OxyR regulon confers the maximum HOCl resistance. PMID: 24899627
    2. The isogenic oxyR mutant exhibited increased H2O2 sensitivity, indistinguishable in vitro growth, and attenuated virulence in rodent models of urinary tract, subcutaneous infection, and systemic sepsis. PMID: 23850958
    3. OxyR serves as a master regulator of S-nitrosylation, and alternative posttranslational modifications of OxyR control distinct transcriptional responses PMID: 22539721
    4. OxyR seems to be a factor stimulating lambda prophage maintenance under conditions of oxidative stress. PMID: 20559623
    5. Data suggest that the redox state of OxyR and Fnr modulates their interaction with the vgb promoter. PMID: 20025616
    6. OxyR activation requires specific disulfide bond formation and that the rapid kinetic reaction path and conformation strain, respectively, drive the oxidation and reduction of OxyR PMID: 15543158
    7. OxyR binds to cis-acting oxidant-responsive elements of the sufA promoter under oxidative stress conditions. PMID: 16824106
    8. Molecular dynamics (MD) simulations have been performed on the regulatory domain of the Escherichia coli OxyR transcription factor for the different chemical states along the mechanistic cycle for its activation by hydrogen peroxide. PMID: 17036142
    9. deletion mutant strains fail to enhance oxidative stress resistance following treatment with tannin and quercetin PMID: 19135521
    10. study examined the contribution of residues at the dimer interface of the transcriptional regulator OxyR to oligomerization PMID: 19177355

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  • 数据库链接：

    KEGG: ecj:JW3933

    STRING: 316385.ECDH10B_4150