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prfA Antibody

  • 货号：
    CSB-PA325257XA01LPY
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: prfA antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31.4 kDa
      Observed band size: 30 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P22262
  • 基因名：
    prfA
  • 别名：
    Listeriolysin regulatory protein, prfA
  • 反应种属：
    Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
  • 免疫原：
    Recombinant Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) Listeriolysin regulatory protein (1-237aa)
  • 免疫原种属：
    Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positively regulates expression of listeriolysin, of 1-phosphadidylinositol phosphodiesterase (PI-PLC) and other virulence factors.
  • 基因功能参考文献：
    1. Spontaneous loss of virulence in natural populations of Listeria monocytogenes due to mutations in hlyA and PrfA has been demonstrated. PMID: 28827366
    2. PepP peptidase plays a role in posttranslational activation of the major virulence regulator, PrfA. PepP mediates recruitment of PrfA to the cytoplasmic membrane. PMID: 28396325
    3. The truncated C-terminus of prfA considerably contributes to the strongly attenuated phenotype observed in vitro. PMID: 25813546
    4. A novel bile exclusion locus bilE, coordinately regulated by sigmaB and PrfA, represents a new and important virulence factor in L. monocytogenes. PMID: 15686563
    5. PrfA K220T amino acid substituted mutant gene in an EGDDeltaprfA strain did not restore the haemolytic and phosphatidylcholine phospholipase C activities, in contrast to the wild-type prfA gene. PMID: 17379709

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  • 数据库链接：

    KEGG: lmo:lmo0200

    STRING: 169963.lmo0200