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ptxA Antibody

  • 货号：
    CSB-PA356423LA01Bua
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Bordella pertussis pertussis toxin subunit 1 antibody at 2μg/ml + recombinant Bordella pertussis pertussis toxin subunit 1 100ng
      Secondary
      Goat polyclonal to rabbit IgG at 1/1000 dilution
      Predicted band size: 36 kDa
      Observed band size: 36 kDa
  • 其他：

产品详情

  • 产品描述：

    The ptxA antibody is a polyclonal antibody produced in rabbit, which specifically binds to the Bordetella pertussis ptxA protein. The immunogen is a synthetic peptide mapping to the amino acids 35-269 of the recombinant Bordetella pertussis Pertussis toxin subunit 1 protein. The antibody has been purified using protein G affinity chromatography, resulting in a purity level greater than 95%. The antibody is of the IgG class and is unconjugated, meaning it can be used in a wide range of applications.

    The ptxA antibody has been validated for use in both ELISA and WB applications. As a result, it is a valuable tool for researchers investigating Bordetella pertussis ptxA and its role in the pathogenesis of whooping cough.

  • 产品名称：
    Rabbit anti-Bordetella pertussis ptxA Polyclonal antibody
  • Uniprot No.：
    P04977
  • 基因名：
    ptxA
  • 别名：
    ptxA antibody; BP3783 antibody; Pertussis toxin subunit 1 antibody; PTX S1 antibody; Islet-activating protein S1 antibody; IAP S1 antibody; NAD-dependent ADP-ribosyltransferase antibody; EC 2.4.2.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Bordetella pertussis
  • 免疫原：
    Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA)
  • 免疫原种属：
    Bordetella pertussis
  • 标记方式：
    Non-conjugated

    本页面中的产品，ptxA Antibody (CSB-PA356423LA01Bua)，的标记方式是Non-conjugated。对于ptxA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA356423LB01Bua ptxA Antibody, HRP conjugated ELISA
    FITC CSB-PA356423LC01Bua ptxA Antibody, FITC conjugated
    Biotin CSB-PA356423LD01Bua ptxA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
  • 基因功能参考文献：
    1. It has been proposed that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. PMID: 28784932
  • 亚细胞定位：
    Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.
  • 蛋白家族：
    Bacterial exotoxin subunit A family
  • 数据库链接：

    KEGG: bpe:BP3783

    STRING: 257313.BP3783