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tbx5a Antibody

  • 货号：
    CSB-PA881254LA01DIL
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) tbx5a Polyclonal antibody
  • Uniprot No.：
    Q9IAK8
  • 基因名：
    tbx5a
  • 别名：
    tbx5a antibody; heartstrings antibody; hst antibody; tbx5 antibody; tbx5.1 antibody; si:ch211-245e21.2 antibody; T-box transcription factor TBX5-A antibody; zftbx5a antibody; T-box protein 5 antibody; zTbx5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish T-box transcription factor TBX5-A protein (1-492AA)
  • 免疫原种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 标记方式：
    Non-conjugated

    本页面中的产品，tbx5a Antibody (CSB-PA881254LA01DIL)，的标记方式是Non-conjugated。对于tbx5a Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA881254LB01DIL tbx5a Antibody, HRP conjugated ELISA
    FITC CSB-PA881254LC01DIL tbx5a Antibody, FITC conjugated
    Biotin CSB-PA881254LD01DIL tbx5a Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters.
  • 基因功能参考文献：
    1. loss of tbx5a function significantly impairs the ability of zebrafish hearts to regenerate after ventricular resection, indicating that Tbx5a plays an essential role in the transcriptional program of heart regeneration. PMID: 29933372
    2. Tbx5a-expressing lineage demonstrates cardiomyocyte plasticity during zebrafish heart regeneration. PMID: 29382818
    3. Regulatory evolution of Tbx5 and the origin of paired appendages, such as fins, is presented. PMID: 27503876
    4. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility. PMID: 26525676
    5. Results show that cul4a but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development. PMID: 25274780
    6. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development. PMID: 24759614
    7. Despite similar spatio-temporal expression patterns, tbx5a and tbx5b have independent functions in heart and fin development. PMID: 23441045
    8. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis PMID: 22776023
    9. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos PMID: 21982178
    10. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20, and has2 in the heart PMID: 20306498
    11. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development. PMID: 20413782
    12. Pdlim7/Tbx5 interactions affect the expression of Tbx5 target genes nppa and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects. PMID: 19895804
    13. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. PMID: 12223419
    14. overexpression of hrT causes a significant downregulation of tbx5, indicating that one key role of hrT is to regulate the levels of tbx5 PMID: 12397116
    15. Tbx5, in addition to its role governing forelimb identity, is both necessary and sufficient for limb outgrowth; Tbx5 functions downstream of WNT signaling to regulate Fgf10, which, in turn, maintains Tbx5 expression during limb outgrowth. PMID: 12399308
    16. Sall gene family redundancy and tbx5 offer explanations for the similarity of individuals with Okihiro syndrome and Holt-Oram syndrome limb defects PMID: 16501170
    17. heart failure caused by the knockdown of tbx5 gene might result from the down-regulation of cardiac myogenesis genes PMID: 18661250
    18. redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis, but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 and tbx20 through the maturation stage PMID: 19158954
    19. the genetic interaction of Tbx5 and Mef2c is not only required for MYH6 expression but also essential for the early stages of heart development and survival PMID: 19204083

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in the dorsal optic cup of developing eye, pectoral fin buds and heart. At 31 hpf, when the pectoral fin buds have begun bulging outwards, restricted expression is detected throughout the mesenchyme of the early fin buds and these high levels of
  • 数据库链接：

    KEGG: dre:30071

    STRING: 7955.ENSDARP00000033053

    UniGene: Dr.81302