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HRH3 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA783626A0HU
  • 规格：
    ￥1320
  • 图片：
    • Overlay Peak curve showing SH-SY5Y cells surface stained with CSB-RA783626A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y5N1
  • 基因名：
  • 别名：
    Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97), HRH3, GPCR97
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from Human HRH3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    27H8
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, FC
  • 推荐稀释比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
  • 基因功能参考文献：
    1. These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation. PMID: 29557708
    2. results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor PMID: 28126588
    3. We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis. PMID: 29253893
    4. These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population PMID: 26989676
    5. Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy. PMID: 26915454
    6. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied. PMID: 25098339
    7. The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. PMID: 24835231
    8. the anatomical localization of Hreceptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission; tt is conceivable that Hreceptors can moderate the development and maintenance of drug addiction. PMID: 23647606
    9. The A280V mutation reduces the signalling efficacy of the human H3 receptor; this effect may be relevant to the pathophysiology of disorders associated with the mutation PMID: 23713487
    10. Report synthesis/functional characterization of imbutamine analogs as histamine H3 agonists. PMID: 24493592
    11. In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease. PMID: 23677734
    12. [review] The H1, H2, and H3 receptors are all involved in recovery of neurological function when extracellular histamine is gradually increasing, after cerebral ischemia. PMID: 22860191
    13. mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients. PMID: 22118942
    14. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R. PMID: 22870296
    15. Significant association of HRH3 with antipsychotic efficacy was detected. PMID: 21652606
    16. study identified novel functional properties in terms of voltage sensitivities and deactivation rates, which differed between the histamine hH3445, hH3365, and H4 receptors PMID: 22885137
    17. Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied. PMID: 22129936
    18. The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling. PMID: 21749919
    19. Data suggest that V-allele genotypes in the H3 receptor gene increase inactive receptors, enhancing inhibition of negative feedback mechanism on the H3 receptor and increasing histamine release, correlating with migraine attacks in susceptible patients. PMID: 21376262
    20. This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity. PMID: 20864503
    21. Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth. PMID: 19825989
    22. Analogous to the effects of alpha(2)-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H(3)R-mediated antiexocytotic effects could result from a decreased Ca(2+) influx into nerve endings PMID: 11752397
    23. The structure of HRH3 has been determined and a missense mutation (Ala280Val) identified in a patient with Shy-Drager syndrome. PMID: 11956964
    24. Molecular cloning of functionally distinct isoforms of the human histamine H(3) receptor PMID: 12069903
    25. Densities of histamine H(3) receptor sites were significantly decreased in patient material. PMID: 12971961
    26. absence of H3 receptor in human skin mast cells PMID: 15191551
    27. The human H(3)receptor gene suggested to consist of either 3 exons and 2 introns, or 4 exons and 3 introns, with ...additional exon accounting for...8 additional carboxy(C)-terminal amino acids...in some human H(3) receptor sequences PMID: 15665857
    28. we describe the biological and chemical implications for developing H3 receptor antagonists and their therapeutic potential as disclosed through animal models of cognition, sleep, and obesity. PMID: 16565470
    29. The purpose of this study was to identify the structural requirements for H3 antagonistic activity via quantitative structure-activity relationship (QSAR) studies and receptor modeling/docking techniques. PMID: 17561422
    30. Histamine excites human enteric neurones and this effect involves histamine H1-4 receptors. PMID: 17627982
    31. Data show that histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. PMID: 18345506
    32. H(3)R is localized mainly around submucosal glands and plays an important role in the secretion of submucosal glands in the nose. PMID: 18564330
    33. role in neurogenic inflammation PMID: 18802338
    34. D1-H3 receptor heteromers constitute unique devices that can direct dopaminergic and histaminergic signalling towards the MAPK pathway in a G(s)-independent and G(i)-dependent manner. PMID: 19413572
    35. Histamine H3 receptors in the prefrontal cortex take part in the modulation of cognition, which is impaired in schizophrenic subjects and bipolar subjects with psychotic symptoms. PMID: 19413576

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are
  • 数据库链接：

    HGNC: 5184

    OMIM: 604525

    KEGG: hsa:11255

    STRING: 9606.ENSP00000342560

    UniGene: Hs.251399