Acetyl-Histone H2B type 1-B (K20) Recombinant Monoclonal Antibody
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货号:CSB-RA010402A20acHU
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规格:¥1320
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图片:
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其他:
产品详情
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产品描述:
The acetyl-Histone H2B type 1-B/HIST1H2BB (K20) recombinant monoclonal antibody is a highly specific antibody against the acetylated HIST1H2BB at K20 from human and mouse sources. This acetyl-HIST1H2BB (K20) antibody was expressed by transfecting the human acetyl-HIST1H2BB (K20)monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. Its isotype matches with the rabbit IgG. This acetyl-HIST1H2BB (K20) antibody can be used in ELISA, WB, ICC, IF, and FC applications.
HIST1H2BB is a subtype of histone core component H2B. Antibodies against the HIST1H2BB are useful for the localization and detection of the HIST1H2BB of acetylation at Lys20 residue.
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Uniprot No.:P33778
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基因名:HIST1H2BB
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别名:HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody
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反应种属:Human
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免疫原:A synthesized peptide
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Monoclonal
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抗体亚型:Rabbit IgG
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纯化方式:Affinity-chromatography
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克隆号:21F11
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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产品提供形式:Liquid
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应用范围:ELISA, WB, ICC, IF, FC
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推荐稀释比:
Application Recommended Dilution WB 1:5000-1:10000 ICC 1:50-1:500 IF 1:30-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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基因功能参考文献:
- Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID: 29643390
- RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID: 26854224
- RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID: 21362548
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亚细胞定位:Nucleus. Chromosome.
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蛋白家族:Histone H2B family
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数据库链接:
HGNC: 4751
OMIM: 602803
KEGG: hsa:3018
STRING: 9606.ENSP00000350580
UniGene: Hs.553494