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  4. IFNAR1 Recombinant Monoclonal Antibody

IFNAR1 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA011046A0HU
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品描述：

    Recombinant IFNAR1 antibody production begins with the obtaining of the antibody genes. This process includes animal immunization, spleen isolation, RNA extraction, DNA synthesis via reverse transcription, and DNA sequencing and screening. Next, the antibody genes were cloned into a plasma vector and then transfected into an appropriate mammalian cell line for expression. The recombinant IFNAR1 antibody was obtained and characterized following transient expression. It was purified using affinity-chromatography. And it can be used to detect the IFNAR1 antibody from Human in the ELISA.

    IFNAR1, together with IFNΑR2, constitutes the interferon-alpha receptor. It binds to the ligand and JAK1, which plays an important role in signal transduction. IFNAR1 deficiency rescues recognition and spatial memory of HIVgp120tg females. Hina Singh et al. has discovered that IFNAR1 plays a prominent role in distinct sex-dependent and independent processes of HIV-1-induced neuronal injury and behavioral impairment.

  • Uniprot No.：
    P17181
  • 基因名：
  • 别名：
    Alpha type antiviral protein antibody; Antiviral protein, alpha-type antibody; Antiviral protein, beta-type antibody; AVP antibody; Beta type antiviral protein antibody; CRF2-1 antibody; Cytokine receptor class-II member 1 antibody; Cytokine receptor family 2 member 1 antibody; IFN alpha REC antibody; IFN alpha receptor antibody; IFN alpha/beta Receptor alpha antibody; IFN beta receptor antibody; IFN Interferon-beta receptor antibody; IFN-alpha/beta receptor 1 antibody; IFN-R-1 antibody; IFNAR antibody; Ifnar1 antibody; IFNBR antibody; IFRC antibody; INAR1_HUMAN antibody; Interferon (alpha beta and omega) receptor 1 antibody; interferon alpha and beta receptor subunit 1 antibody; Interferon alpha/beta receptor 1 antibody; Interferon alpha/beta receptor alpha chain antibody; Interferon beta receptor 1 antibody; interferon receptor 1 antibody; Interferon-alpha receptor antibody; Type I interferon receptor 1 antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human IFNAR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1B12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
  • 基因功能参考文献：
    1. IFNAR1 signaling underlies an increased risk of tuberculosis in humans and reveals a function for the IFNAR1 inter-domain region in cytokine-cytokine receptor interaction and signal transduction. PMID: 29311663
    2. HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. PMID: 29375208
    3. Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts. PMID: 28282804
    4. cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1. PMID: 29343571
    5. The s find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The s further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
    6. Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer. PMID: 28842285
    7. Here, we review the current knowledge on the main strategies that human pathogenic flaviviruses utilize to escape both type I IFN induction and effector pathways. [review] PMID: 28576494
    8. the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy. PMID: 27346865
    9. Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche. PMID: 28196594
    10. These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication. PMID: 27569280
    11. this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo in Estonian patients PMID: 26429320
    12. A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1. PMID: 25072284
    13. rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations. PMID: 26679744
    14. Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection. PMID: 25939635
    15. data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling PMID: 26787880
    16. Data suggest IFNA2 (interferon, alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes. PMID: 26679999
    17. These findings suggest that influenza A virus hemagglutinin causes IFNAR1 degradation, which in turn helps the virus escape the powerful innate immune system. PMID: 26676772
    18. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
    19. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients PMID: 25675103
    20. The expression of IFNAR1, IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers. PMID: 25265476
    21. Results show that SNPs in IFNAR1 and IFNG were risk factors for malaria in Indian population. PMID: 25445652
    22. sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to chronic hepatitis B. PMID: 25501140
    23. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
    24. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
    25. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection. PMID: 23663046
    26. [review] The type I interferon system has an important role in the pathogenesis of Sjogren's syndrome. PMID: 23201923
    27. Results identified genetic variants in interferon genes that influence melanoma progression and survival with modulation of effect due to treatment status. PMID: 23209811
    28. PTP1B is a specific regulator of IFNAR1 endocytosis. PMID: 23129613
    29. common genetic changes in IFNAR1 may influence HCC risk, likely through miR-1231-mediated regulation. PMID: 22824466
    30. These new findings reveal distinct and overlapping signaling mechanisms used by B-cell antigen receptor and IFNAR in the regulation of TLR7 tolerance and activation. PMID: 22786773
    31. Systemic lupus erythematosus patients are found to have the highest serum type I IFN activity; in contrast, the untreated relapsing-remitting multiple sclerosis population has the lowest levels of endogenous IFN-alpha/beta activity. PMID: 22036215
    32. 2A protease encoded by EV71 as an antagonist of IFNB1 and the protease activity is required for reducing IFNAR1 levels. PMID: 22258259
    33. HBX expression downregulates type I IFN receptor, leading to disturbance of extracellular type I IFN signaling. PMID: 22218495
    34. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
    35. Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes. PMID: 22162633
    36. Early progenitors and mature megakaryocytes, but not platelets, express functional IFNAR and synthetize/release IFN-beta, revealing not only that megakaryo/thrombopoiesis regulation by IFN-I is associated with a specific interaction with its receptor PMID: 22136495
    37. IFNalphaR is dispensable on responding CD4+ T cells. Cells derived from transgenic bone marrow are sufficient to restore IFNalphaR-dependent pathways in IFNalphaR-deficient mice. PMID: 22156349
    38. Tyrosine phosphorylation of PKD2 is required for IFNalpha-stimulated activation of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ensuing restriction of the extent of cellular responses to IFNalpha. PMID: 21865166
    39. In cells exposed to VEGF, phosphorylation-dependent degradation of IFNAR1 leads to an inhibition of type 1 IFN signaling and is required for efficient VEGF-stimulated angiogenesis. PMID: 21832278
    40. The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of hepatitis C virus to exogenous interferon alpha. PMID: 21756311
    41. These data demonstrate that West Nile virus infection results in a reduction of IFNAR1 protein through a non-canonical protein degradation pathway, and may participate in the inhibition of the interferon response. PMID: 21830897
    42. activation of p38 kinase in response to pathogen-recognition receptors stimulation results in a series of phosphorylation events within the IFNAR1 chain of the Type I IFN receptor PMID: 21695243
    43. The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
    44. A low number of receptors suffices for antiviral response and is thus a robust feature common to all cells. Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level. PMID: 21690295
    45. an important role of p38 kinase in the ligand-independent stimulation of IFNAR1 ubiquitination and degradation PMID: 21540188
    46. Expression and kinase activity of PKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1. PMID: 21173164
    47. Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. PMID: 19957332
    48. These results suggest that a combination of serum soluble interferon-alpha/beta receptor and high-sensitivity-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer. PMID: 19879773
    49. The expression of interferon-alpha receptor in liver tissues in patients with chronic hepatitis B correlates well with the pathological grading and alanine aminotransferase level. PMID: 19220955
    50. The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. PMID: 20020050

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome.
  • 蛋白家族：
    Type II cytokine receptor family
  • 组织特异性：
    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resi
  • 数据库链接：

    HGNC: 5432

    OMIM: 107450

    KEGG: hsa:3454

    STRING: 9606.ENSP00000270139

    UniGene: Hs.529400