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  4. Recombinant Androctonus mauretanicus mauretanicus Potassium channel toxin alpha-KTx 15.3

Recombinant Androctonus mauretanicus mauretanicus Potassium channel toxin alpha-KTx 15.3

  • 货号：
    CSB-YP350912AKB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP350912AKB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP350912AKB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP350912AKB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP350912AKB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Potassium channel toxin alpha-KTx 15.3; Toxin AmmTX3
  • 种属：
    Androctonus mauretanicus mauretanicus (Scorpion)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    1-37
  • 氨基酸序列
    QIETNKKCQG GSCASVCRKV IGVAAGKCIN GRCVCYP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits A-type (Kv4) voltage-gated potassium channels of striated neurons (Ki=131 nM), probably by acting as a pore blocker. Has also been shown to block ERG1/Kv11.1/KCNH2 potassium channels (IC(50)=7.9 uM). The presence of the Kv4-associated proteins DPP6 or DPP10 is mandatory to have high-affinity blockade of Kv4.2/KCND2 and Kv4.3/KCND3 channels (80-90% inhibition at 500 nM of toxin). In contrast, the presence of the Kv4-associated protein KChIP1/KCNIP1 does not enhance the affinity blockade (only 40% inhibition at 500 nM). In adult rat brain, the toxin binds to sites in the striatum, and cerebellum. It shares the same target in rat brain than AaTX1 (AC Q867F4) and BmTX3 (AC Q8I0L5). In DPP6 knockout mice, A-type currents are about 20-fold less affected by the toxin. In rodent models of Parkinson's disease, the toxin reduces motor symptoms and emotional and cognitive symptoms.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily
  • 组织特异性：
    Expressed by the venom gland.