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  4. Recombinant Arabidopsis thaliana Abscisic acid receptor PYR1 (PYR1)

Recombinant Arabidopsis thaliana Abscisic acid receptor PYR1 (PYR1)

  • 中文名称：
    拟南芥PYR1重组蛋白
  • 货号：
    CSB-YP527416DOA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    拟南芥PYR1重组蛋白
  • 货号：
    CSB-EP527416DOA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    拟南芥PYR1重组蛋白
  • 货号：
    CSB-BP527416DOA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    拟南芥PYR1重组蛋白
  • 货号：
    CSB-MP527416DOA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PYR1
  • Uniprot No.：
  • 别名：
    PYR1; ABIP6; RCAR11; At4g17870; T6K21.50; Abscisic acid receptor PYR1; ABI1-binding protein 6; Protein PYRABACTIN RESISTANCE 1; Regulatory components of ABA receptor 11
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-191
  • 氨基酸序列
    MPSELTPEER SELKNSIAEF HTYQLDPGSC SSLHAQRIHA PPELVWSIVR RFDKPQTYKH FIKSCSVEQN FEMRVGCTRD VIVISGLPAN TSTERLDILD DERRVTGFSI IGGEHRLTNY KSVTTVHRFE KENRIWTVVL ESYVVDMPEG NSEDDTRMFA DTVVKLNLQK LATVAEAMAR NSGDGSGSQV T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA. Promotes drought tolerance.
  • 基因功能参考文献：
    1. study suggests both nuclear and cytoplasmic PYR1 participate in the control of ABA signal transduction PMID: 28109881
    2. The transgenic plants show an acute abscisic acid (ABA) insensitivity, demonstrating the importance of ABA-mediated PYR/PYL/RCAR-PP2C contacts for receptor function in vivo. PMID: 21357183
    3. Pyr1 receptor contributes to ozone, reduced air humidity and darkness induced stomatal regulation. PMID: 23703845
    4. findings are generally consistent with the competitive-interaction model for PYR1 but highlight dynamical contributions of the PYR1 structure in mediating interaction selectivity PMID: 23825939
    5. This work illustrates how oligomerization of abscisic acid receptors can modulate hormonal responses in Arabidopsis and more generally, the sensitivity of a ligand-dependent signalling system. PMID: 21847091
    6. Subtle changes in the binding pockets of PYR/PYL proteins control ligand orientation inside the pocket, and this is sufficient to explain whether pyrabactin acts as an effective receptor agonist. [PYR1] PMID: 20729860
    7. X-ray data is reported for PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid. The three proteins crystallize in space groups P3(1)21/P3(2)21, P2 and P1, respectively. X-ray intensity data were collected to 1.9-2.6 A resolution. PMID: 20383021
    8. findings show that abscissic binds to PYRABACTIN RESISTANCE 1 (PYR1),At4g17870, which in turn binds to and inhibits Type 2C protein phosphatases (HAB1) PMID: 19407142
    9. the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA. PMID: 19898494
    10. structure of pyrabactin resistance 1 (PYR1); structure reveals an alpha/beta helix-grip fold & homodimeric assembly; abscisic acid (ABA) binding within a large internal cavity switches structural motifs distinguishing ABA-free from ABA-bound conformations PMID: 19933100

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Nucleus. Cell membrane. Vacuole.
  • 蛋白家族：
    PYR/PYL/RCAR abscisic acid intracellular receptor family
  • 数据库链接：

    KEGG: ath:AT4G17870

    STRING: 3702.AT4G17870.1

    UniGene: At.2045