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  4. Recombinant Arabidopsis thaliana Cyclin-dependent kinase inhibitor 6 (KRP6)

Recombinant Arabidopsis thaliana Cyclin-dependent kinase inhibitor 6 (KRP6)

  • 中文名称：
    拟南芥KRP6重组蛋白
  • 货号：
    CSB-YP605878DOA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    拟南芥KRP6重组蛋白
  • 货号：
    CSB-EP605878DOA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    拟南芥KRP6重组蛋白
  • 货号：
    CSB-EP605878DOA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    拟南芥KRP6重组蛋白
  • 货号：
    CSB-BP605878DOA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    拟南芥KRP6重组蛋白
  • 货号：
    CSB-MP605878DOA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KRP6
  • Uniprot No.：
  • 别名：
    KRP6; ACK1; ICK4; At3g19150; MVI11.5Cyclin-dependent kinase inhibitor 6; Cyclin-dependent kinase inhibitor p22ack1; Inhibitor/interactor of CDK protein 4; KIP-related protein 6
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-196
  • 氨基酸序列
    MSERKRELAE EASSTSFSPL KKTKLNDSSD SSPDSHDVIV FAVSSSSVAS SAALASDECS VTIGGEESDQ SSSISSGCFT SESKEIAKNS SSFGVDLEDH QIETETETST FITSNFRKET SPVSEGLGET TTEMESSSAT KRKQPGVRKT PTAAEIEDLF SELESQDDKK KQFIEKYNFD IVNDEPLEGR YKWDRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. May inhibit CDK kinases specifically involved in the G1/S phase transition.
  • 基因功能参考文献：
    1. Data suggest the cell cycle uncouples gibberellic acid (GA) and abscisic Acid (ABA) responses in germinating seeds, and that cell cycle regulator KRP6 acts downstream of GA to inhibit mitotic cell cycle activation during germination. PMID: 27021201
    2. KRP6 is involved in multinucleation and acytokinesis occurring in giant-cells. PMID: 25915833
    3. Phosphorylation of KRP6 and KRP7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation. PMID: 23617622
    4. Results suggest that p22(ack1) and cyclin D1, which act antagonistically, are major rate-limiting factors for cell division in the leaf meristem [p22ack1] PMID: 15464981
    5. ACK1 acts as a cyclin dependent kinase inhibitor in Arabidopsis PMID: 15809079

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Note=Homogeneously distributed. Present in microspores and accumulates strongly in vegetative cell nuclei immediately after asymmetric division and disappears later.
  • 蛋白家族：
    CDI family, ICK/KRP subfamily
  • 组织特异性：
    Expressed in newly formed organs such as the shoot apex. Expressed in cotyledon, primary root and marginal region of the leaves as well as in developing pollen.
  • 数据库链接：

    KEGG: ath:AT3G19150

    STRING: 3702.AT3G19150.1

    UniGene: At.8228