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  4. Recombinant Arabidopsis thaliana Protection of telomeres protein 1a (POT1A)

Recombinant Arabidopsis thaliana Protection of telomeres protein 1a (POT1A)

  • 中文名称：
    拟南芥POT1A重组蛋白
  • 货号：
    CSB-YP704105DOA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    拟南芥POT1A重组蛋白
  • 货号：
    CSB-EP704105DOA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    拟南芥POT1A重组蛋白
  • 货号：
    CSB-EP704105DOA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    拟南芥POT1A重组蛋白
  • 货号：
    CSB-BP704105DOA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    拟南芥POT1A重组蛋白
  • 货号：
    CSB-MP704105DOA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    POT1A
  • Uniprot No.：
  • 别名：
    POT1A; POT1; At2g05210; F5G3; Protection of telomeres protein 1a; AtPOT1a; AtPot1; Protection of telomeres protein 1
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-467
  • 氨基酸序列
    MAKKRESPKL IKIKDAIKLI NQQVSLIGIV LEQREPKQCR NNDWICTLRI IDDTYPSPGL TVNVFSKTLE QLPQIKNHDD MILFTRIKMQ TFDSGERVNA ACSRWVSSFA LFEGVDFVCY QCSTNFHEEE ALYKSAMDDL RKVFAGCSQV IKAMQSISYR TKPCSEVFSF LREIKIGKRF DLVCRILHAD EDTSAVFVWD GTDAPPASIL AKRSEEDKAF SSLSVHTLLS RDVLLSFPTV GTILRVHLSS HLFYRVKPGD WVKLYHLLCE VDRGSWVIKV TSSTKVHHLA QDDRLVEKIM RIYDKRLSSK LGHISFWCFP SPPGLTETDD NCAPFVTLMD IITFPKVTCK YRCIVRVVAA YPWQVEDFCS DENRRHHQVL LTLEDSTATL EAFLCNKDAE YFWGLGFQDT ETLRKKRNWL LGIRESSNFV APRNPPWIEC CILSYYTNKA DPWNTRLYRI FGTRLLH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the positive regulation of telomere length. Binds RNA non-specifically. Binds specifically single-stranded telomeric DNA. Not required to recruit telomerase to telomeres, but stimulates TER1 RNP repeat addition processivity.
  • 基因功能参考文献：
    1. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions. PMID: 25329641
    2. Our results reveal a molecular mechanism for the role of these positively selected sites in AtPOT1a. PMID: 25697340
    3. AtPot1 (protection of telomeres 1) and AtPot2 are ubiquitously expressed at low levels in Arabidopsis. AtPot1 is essential for telomere length maintenance. [Atpot1] PMID: 16107718
    4. Single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins. PMID: 19228335
  • 亚细胞定位：
    Nucleus. Chromosome, telomere. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Telombin family
  • 组织特异性：
    Expressed in roots, rosette leaves, cauline leaves, stems and flowers.
  • 数据库链接：

    KEGG: ath:AT2G05210

    STRING: 3702.AT2G05210.1

    UniGene: At.48422