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  4. Recombinant Bombina variegata Prokineticin Bv8

Recombinant Bombina variegata Prokineticin Bv8

  • 中文名称：
    Recombinant Bombina variegata Prokineticin Bv8,Yeast
  • 货号：
    CSB-YP886112BIC
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bombina variegata Prokineticin Bv8,Yeast
  • 货号：
    CSB-EP886112BIC
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bombina variegata Prokineticin Bv8,Yeast
  • 货号：
    CSB-EP886112BIC-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bombina variegata Prokineticin Bv8,Yeast
  • 货号：
    CSB-BP886112BIC
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bombina variegata Prokineticin Bv8,Yeast
  • 货号：
    CSB-MP886112BIC
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Prokineticin Bv8
  • 种属：
    Bombina variegata (Yellow-bellied toad)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-96
  • 氨基酸序列
    A VITGACDKDV QCGSGTCCAA SAWSRNIRFC IPLGNSGEDC HPASHKVPYD GKRLSSLCPC KSGLTCSKSG EKFKCS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Shows an EC(50) of 0.264 nM, when tested on neuroblastoma cells (SH-SY5Y) which endogenously express mainly PKR2/PROKR2. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. Induces a biphasic hyperalgesia to tactile and thermal stimuli after systemic injection of this protein into rat. The initial phase of hyperalgesia is caused by a local action on nociceptors, because intraplantar injection of this protein causes a strong and localized hyperalgesia with a similar time course to that of the initial phase of hyperalgesia seen with systemic injection. The secondary phase of hyperalgesia is not seen with local intraplantar injection and is therefore probably attributable to a central action of this protein. At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, this protein potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (at nanomolar concentration).
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    AVIT (prokineticin) family
  • 组织特异性：
    Expressed by the skin glands.