Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Borrelia burgdorferi Decorin-binding protein A (dbpA)

Recombinant Borrelia burgdorferi Decorin-binding protein A (dbpA)

  • 货号：
    CSB-YP529895BUD
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP529895BUD
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP529895BUD-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP529895BUD
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP529895BUD
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    dbpA
  • Uniprot No.：
  • 别名：
    dbpA; BB_A24Decorin-binding protein A
  • 种属：
    Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-191
  • 氨基酸序列
    A TKIRLERSAK DITDEIDAIK KDAALKGVNF DAFKDKKTGS GVSENPFILE AKVRATTVAE KFVIAIEEEA TKLKETGSSG EFSAMYDLMF EVSKPLQKLG IQEMTKTVSD AAEENPPTTA QGVLEIAKKM REKLQRVHTK NYCTLKKKEN STFTDEKCKN N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.
  • 基因功能参考文献：
    1. the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket PMID: 25695518
    2. Through biophysical and structural analysis of DBPA from strain B31, we have discovered a novel and important GAG-binding epitope in B31 DBPA. Removal of the epitope greatly attenuated its affinity for DBPA. PMID: 24148022
    3. Increasing DbpA expression dramatically increases the interaction of B. burgdorferi with decorin and sensitivity to growth inhibition and killing by anti-DbpA antibodies. PMID: 17562764
    4. Taken together, the study results indicate that neither DbpA nor DbpB is essential for mammalian infection but that both are critical for the overall virulence of B. burgdorferi. PMID: 18195034
    5. DbpBA is not required for the natural tick-transmission process to mammals PMID: 18507835

    显示更多

    收起更多

  • 蛋白家族：
    Decorin-binding protein family
  • 数据库链接：

    KEGG: bbu:BB_A24