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  4. Recombinant Bovine Insulin-like growth factor-binding protein 3 (IGFBP3)

Recombinant Bovine Insulin-like growth factor-binding protein 3 (IGFBP3)

  • 货号：
    CSB-YP011097BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011097BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011097BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011097BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011097BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IGFBP3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-291
  • 氨基酸序列
    GAG TMGAGPVVRC EPCDARAVAQ CAPPPPSPPC AELVREPGCG CCLTCALREG QPCGVYTERC GSGLRCQPPP GDPRPLQALL DGRGLCANAS AVGRLRPYLL PSASGNGSES EEDHSMGSTE NQAGPSTHRV PVSKFHPIHT KMDVIKKGHA KDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNML SPRGIHIPNC DKKGFYKKKQ CRPSKGRKRG FCWCVDKYGQ PLPGFDVKGK GDVHCYSMES K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
  • 基因功能参考文献：
    1. The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3. PMID: 28003146
    2. These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect. PMID: 26340041
    3. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle. PMID: 21940120
    4. spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies PMID: 14561651
    5. stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK pathways in bovine mammary epithelial cells PMID: 15192040
    6. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of IGFBP-3 PMID: 15927849
    7. GH, IGF-I and IGF-IBP3 regulated the growth and development traits in different growth period. PMID: 16870578
    8. delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes PMID: 18491951
    9. Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction PMID: 18703768
    10. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. PMID: 19259947

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Plasma; expressed by most tissues.
  • 数据库链接：

    KEGG: bta:282261

    STRING: 9913.ENSBTAP00000047769

    UniGene: Bt.64897