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  4. Recombinant Bovine tRNA (guanine-N (7)-)-methyltransferase subunit WDR4 (WDR4)

Recombinant Bovine tRNA (guanine-N (7)-)-methyltransferase subunit WDR4 (WDR4)

  • 货号：
    CSB-YP026021BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026021BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026021BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026021BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026021BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WDR4
  • Uniprot No.：
  • 别名：
    WDR4tRNA; guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-414
  • 氨基酸序列
    ASSAGLALC GHALVVRGGS RLLATSTSSS DGDSLFIYDC SAAEKKSQEN KGEDGQPVDQ GSDTVLASTF SKSGSYFVLT DDSKRLILFR TNPWQCLSVR TVVRRCTALT FTASEEKILV ADKSGDVYSF SVLEPHGGGR LELGHLSMLL DVAVSPDDRF VLTADRDEKI RVSWAAAPHS IESFCLGHTE FVSRIFVVPN HPELLLSSSG DCTLRLWEYR SGRELHCCPL TSLQEPTEPW SDKRFAVSRI TYWSQEDCVA LSCDGLPVVY IFQLDAAQRQ LVPRQLLTFQ HRVWDAAFEE GHGLWVLQDC REDPLVLYRP VGGQWQSAPE SAELRRVCAH VRVNWAMLEG CAGVDSGFSS LYKATCDNMT TYLKKKEERL QQQLEKKRRQ APPPGPNGPT KKMRAGELAQ GCSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Acts as a regulator of embryonic stem cell self-renewal and differentiation. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1.
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    WD repeat TRM82 family
  • 数据库链接：

    KEGG: bta:508051

    STRING: 9913.ENSBTAP00000028643

    UniGene: Bt.36135