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  4. Recombinant Casein kinase I isoform delta (kin-20)

Recombinant Casein kinase I isoform delta (kin-20)

  • 货号：
    CSB-YP633618CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP633618CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP633618CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP633618CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP633618CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    kin-20
  • Uniprot No.：
  • 别名：
    kin-20; F46F2.2Casein kinase I isoform delta; EC 2.7.11.1; Protein kinase 20
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-497
  • 氨基酸序列
    MATMSNDAAA AATWHNNTST PMDTTEPATN SHNPGETAVI GGPEALLLPS GSGPEEMNRH PLLMAQAHGE HHQPRLLHNF PVIPPPIQQH QQPPLLQQAQ PSQIPHPTQP QIDPTMFTQQ SGFNWPPIDP NTIAALAQAQ LASSHAQFVS LALTLDPTLL SHFLATQQIP PVPQPLVHKK AEMELRVGNR FRLGRKIGSG SFGDIYLGQN IQTNEEVAVK LECVKSKHPQ LHIESRLYRI MLGGIGIPEI RWCGQEGDYN VMVMELLGPS LEDLFNFCQR KFSLKTVLLL ADQMLSRVEF IHCRDYIHRD IKPDNFLMGL GKRGNLVYII DFGLAKRYRD SKHQHIAYRE NKNLTGTARY ASINTHRGIE QSRRDDIESL GYVFMYFNRG TLPWQGLKAV TKRQKYELIS EKKISTRVDD LCAGYPEAFA QYLNYCRSLG FEEQPDYGYL RNLFRTLFHR QQFCYDYVFD WNTYKFYNES LEARNNFQQA VPNQRRH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. Casein kinases are operationally defined by their preferential utilization of acidic proteins. Positively regulates the expression of components of the heterochronic pathway, which regulate developmental timing, such as the transcriptional repressor lin-42 and microRNAs such as let-7. Negatively regulates cell cycle exit and cell fusion to prevent the premature differentiation of hypodermal seam cells into adult cells. Plays a role in regulating axon branching and subsequently, the maturation of the nervous system, most likely by preventing the premature termination of transcripts for proteins such as Ankyrin/unc-44, which are required for maintaining the nervous system. May phosphorylate ssup-72 to promote nervous system maturation (Probable).
  • 基因功能参考文献：
    1. Worms containing a large deletion in kin-20 have a significantly smaller brood size and develop slower than wild type C. elegans. kin-20 is important for post-transcriptional regulation of mature let-7 and lin-4 microRNA expression. PMID: 29880558
  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome, centromere. Cell junction, adherens junction.
  • 蛋白家族：
    Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
  • 组织特异性：
    Expressed throughout larval development and into the adult stage in both hypodermal seam cells and the hermaphrodite specific neuron.
  • 数据库链接：

    KEGG: cel:CELE_F46F2.2

    STRING: 6239.F46F2.2c.2

    UniGene: Cel.996