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  4. Recombinant Cat Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Recombinant Cat Cyclin-dependent kinase inhibitor 1 (CDKN1A)

  • 货号：
    CSB-YP005086CA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005086CA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005086CA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005086CA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005086CA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CDKN1A; CIP1; WAF1Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; p21
  • 种属：
    Felis catus (Cat) (Felis silvestris catus)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-164
  • 氨基酸序列
    SEPSRDAHQ IPHGSKACRR LFGPVDSEQL RRDCDALMAG CVQEARERWN FDFVTETPLE GDFAWERVWG LGLPKLYLPA GPRGGRDDLG GGKRPSTSST LLPGTAREDH LDLSLSCTLM PHSPERPEAS PGAPGTSQGR KRRQTSMTDF YHSKRRLIFS KRKP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest.
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CDI family
  • 数据库链接：

    KEGG: fca:493943

    STRING: 9685.ENSFCAP00000020450