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  4. Recombinant Chicken Activity-regulated cytoskeleton-associated protein (ARC)

Recombinant Chicken Activity-regulated cytoskeleton-associated protein (ARC)

  • 货号：
    CSB-YP001981CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001981CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001981CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001981CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001981CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARC
  • Uniprot No.：
  • 别名：
    ARCActivity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein homolog; ARC/ARG3.1; Arg3.1
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-404
  • 氨基酸序列
    MQLDNVTNAG IHSFQGHRGV ANKPNVILQI GKCRAEMLEH VRRTHRHLLS EVSKQVEREL KGLQKSVGKL ENNLEDHVPT DNQRWKKSIK ACLARCQETI AHLERWVKRE MNVWKEVFFR LEKWADRLES MGGKYCPGEH GKQTVSVGVG GPEIRPSEGE IYDYALDMSQ MYALTPAPGE VPSIPQAHDS YQWVSVSEDA PASPVETQIF EDPHEFLSHL EEYLKQVGGT EEYWLSQIQN HMNGPAKKWW EYKQDSVKNW VEFKKEFLQY SEGTLTRDAI KRELDLPQKE GEPLDQFLWR KRDLYQTLYV DADEEEIIQY VVGTLQPKLK RFLSYPLPKT LEQLIQRGKE VQGNMDHSEE PSPQRTPEIQ SGDSVESMPP STTASPVPSN GTQPEPPSPP ATVI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material.
  • 基因功能参考文献：
    1. both the Arc/arg3.1 and zenk genes are induced by auditory imprinting, they are significantly up-regulated in different learning-relevant brain regions PMID: 15908132
  • 亚细胞定位：
    Extracellular vesicle membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Early endosome membrane. Cell projection, dendrite. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, dendritic spine.
  • 蛋白家族：
    ARC/ARG3.1 family
  • 组织特异性：
    Expressed at various levels throughout the brain.
  • 数据库链接：

    KEGG: gga:395075

    STRING: 9031.ENSGALP00000025980

    UniGene: Gga.20810