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  4. Recombinant Chicken Heat shock factor protein 1 (HSF1)

Recombinant Chicken Heat shock factor protein 1 (HSF1)

  • 中文名称：
    鸡HSF1重组蛋白
  • 货号：
    CSB-YP010791CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡HSF1重组蛋白
  • 货号：
    CSB-EP010791CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡HSF1重组蛋白
  • 货号：
    CSB-EP010791CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡HSF1重组蛋白
  • 货号：
    CSB-BP010791CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡HSF1重组蛋白
  • 货号：
    CSB-MP010791CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HSF1
  • Uniprot No.：
  • 别名：
    HSF1; Heat shock factor protein 1; HSF 1; HSF 3A; HSTF 3A; Heat shock transcription factor 1; HSTF 1
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-491
  • 氨基酸序列
    MEGPGAAAAA VGAGPGGSNV SAFLTKLWTL VEDPETDPLI CWSPSGNSFH VFDQGQFAKE VLPKYFKHNN MASFVRQLNM YGFRKVVHIE QGGLVKPEKD DTEFQHPYFI RGQEHLLENI KRKVTSVSSI KNEDIKVRQD NVTKLLTDIQ VMKGKQESMD SKLIAMKHEN EALWREVASL RQKHAQQQKV VNKLIQFLIS LVQSNRILGV KRKIPLMLND SSSAHSMPKY SRQYSLEHVH GSSPYAASSP AYSGSNIYSP DSSTNSGPII SDVTELAQSS PSASPSGSLD ERSSPVVRIK EEPPSPSRSP KENEPSTTTA AAGNSTEQPQ PQEKCLSVAC LDKNELNDHL DTIDSNLDNL QTMLSTHGFS VDTTALLDLF SPSMTVTDMN LPDLDSSLAS IQDLLSSQEQ QKPSEADAAA ADTGKQLVHY TAQPLFLVDS SAVDVGSGDL PIFFELGEGS YFTDGDEYNE DPTISLLSGT EQPKPKDPTV S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells. Plays a role in nuclear export of stress-induced mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation.
  • 基因功能参考文献：
    1. Data suggest that exposure to high environmental temperature up-regulates expression of heat shock factor 1 (HSF1) mRNA, HSF3 mRNA, and heat shock protein 70 (HSP70) mRNA/protein in liver, heart, and breast muscle; dietary supplementation with manganese down-regulates expression of HSP70 in breast muscle. PMID: 27890044
  • 亚细胞定位：
    Nucleus. Cytoplasm. Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    HSF family
  • 组织特异性：
    Low expression found in most tissues with the exception of blood and liver. Highest levels are found in the pigmental layer of retina and in the lymphoblastoid cell line MSB-1.
  • 数据库链接：

    KEGG: gga:420362

    STRING: 9031.ENSGALP00000026456

    UniGene: Gga.51526