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  4. Recombinant Chicken Insulin-like growth factor II (IGF2)

Recombinant Chicken Insulin-like growth factor II (IGF2)

  • 中文名称：
    鸡IGF2重组蛋白
  • 货号：
    CSB-YP011088CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡IGF2重组蛋白
  • 货号：
    CSB-EP011088CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡IGF2重组蛋白
  • 货号：
    CSB-EP011088CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡IGF2重组蛋白
  • 货号：
    CSB-BP011088CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡IGF2重组蛋白
  • 货号：
    CSB-MP011088CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IGF2Insulin-like growth factor II; IGF-II
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-91
  • 氨基酸序列
    AYGTAET LCGGELVDTL QFVCGDRGFY FSRPVGRNNR RINRGIVEEC CFRSCDLALL ETYCAKSVKS E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.
  • 基因功能参考文献：
    1. we found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223 PMID: 28981085
    2. IGF1 and IGF2 might separately be more important for muscle and liver growth in chick embryonic development. Variation of IGFs expression during the incubation might be concerned with the methylation of gene promoter. PMID: 26944971
    3. These findings implied that polymorphisms within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits. PMID: 20379887
    4. IGF2 is a candidate gene influencing growth and carcass traits, and has biallelic expression. PMID: 15986892
    5. These results suggest that the mechanism of action whereby IGFBP2 excess impairs long bone development is to inhibit IGF-I and IGF-II-mediated proliferation and matrix synthesis. PMID: 16183342
    6. These findings provide the first evidence for a potential role of the insulin-like growth factor II-vitronectin complex during the endothelial-to-mesenchymal transition process. PMID: 16831197
    7. Blood levels of IGF-II may be a more important functionary for chick embryonic development than IGF-I. PMID: 17369538

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 数据库链接：

    KEGG: gga:395097

    STRING: 9031.ENSGALP00000010570

    UniGene: Gga.8511