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  4. Recombinant Chicken Transcription factor SOX-2 (SOX2)

Recombinant Chicken Transcription factor SOX-2 (SOX2)

  • 货号：
    CSB-YP022426CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022426CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022426CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022426CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022426CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SOX2; Transcription factor SOX-2; cSox2; delta EF2a
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-315
  • 氨基酸序列
    MYNMMETELK PPAPQQTSGG GTGNSNSAAN NQKNSPDRVK RPMNAFMVWS RGQRRKMAQE NPKMHNSEIS KRLGAEWKLL SEAEKRPFID EAKRLRALHM KEHPDYKYRP RRKTKTLMKK DKYTLPGGLL APGTNTMTTG VGVGATLGAG VNQRMDSYAH MNGWTNGGYG MMQEQLGYPQ HPGLNAHNAA QMQPMHRYDV SALQYNSMTS SQTYMNGSPT YSMSYSQQGT PGMALGSMGS VVKTESSSSP PVVTSSSHSR APCQAGDLRD MISMYLPGAE VPEPAAPSRL HMSQHYQSAP VPGTAINGTL PLSHM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
  • 基因功能参考文献：
    1. Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. PMID: 29352015
    2. Data obtained in this study deciphers a novel role of hindbrain boundaries as repetitive pools of neural stem/progenitor cells, which provide proliferating progenitors and differentiating neurons in a Sox2-dependent regulation. PMID: 27392568
    3. Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. PMID: 24501124
    4. Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling. PMID: 23314866
    5. The results of this study suggested that high levels of Sox2 inhibit progression of neurogenesis in the developing inner ear PMID: 23447599
    6. Sensory competence is established early in otic development through the activation of Atoh1 by Sox2, however, hair cell differentiation is prevented until later stages by the parallel activation of negative regulators of Atoh1 function. PMID: 22292066
    7. A 110-bp minimal essential sequence of SOX2 regulatory enhancer element N-4 is identified, containing 9 regulatory elements involved in activation in cephalic ectoderm, in CNS and in mesencephalon. PMID: 20507355
    8. inhibits neural crest formation as a transcriptional activator and regulates proliferation and differentiation in developing peripheral nervous system PMID: 14699579
    9. involvement of Group B1 Sox functions in N-cadherin regulation via enhancers having activity in the early CNS and/or sensory placodes but with unique spatiotemporal specificities PMID: 16150435
    10. Wnt and FGF signals converge to activate Sox2 expression through the enhancer N-1c, revealing the direct involvement of the Wnt signal in the initiation of neural plate development. PMID: 16354715
    11. The present study shows that SOX2 protein is expressed in a spatially and temporally restricted manner throughout development of the chick inner ear. PMID: 17534940
    12. interactions between three coiled-coil domain proteins (ERNI, Geminin, and BERT), the heterochromatin proteins HP1alpha and HP1gamma acting as repressors, and the chromatin-remodeling enzyme Brm acting as activator control the N2 enhancer. PMID: 18184035
    13. Sox2 can initiate a reprogramming of retinal pigment epithelium cells to differentiate toward retinal neurons and may engage bFGF during the process. PMID: 19489100

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neu
  • 数据库链接：

    KEGG: gga:396105

    STRING: 9031.ENSGALP00000014363

    UniGene: Gga.601