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  4. Recombinant Chicken Transcription factor SOX-9 (SOX9)

Recombinant Chicken Transcription factor SOX-9 (SOX9)

  • 中文名称：
    鸡SOX9重组蛋白
  • 货号：
    CSB-YP022437CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡SOX9重组蛋白
  • 货号：
    CSB-EP022437CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡SOX9重组蛋白
  • 货号：
    CSB-EP022437CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡SOX9重组蛋白
  • 货号：
    CSB-BP022437CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡SOX9重组蛋白
  • 货号：
    CSB-MP022437CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SOX9; Transcription factor SOX-9
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-494
  • 氨基酸序列
    MNLLDPFMKM TEEQDKGLSG APSPTMSDDS AGSPCPSGSG SDTENTRPPQ ENTFPKGDPD LKKESDEDKF PVCIREAVSQ VLKGYDWTLV PMPVRVNGSS KNKPHVKRPM NAFMVWAQAA RRKLADQYPH LHNAELSKTL GKLWRLLNES EKRPFVEEAE RLRVQHKKDH PDYKYQPRRR KTVKNGQSEQ EEGSEQTHIS PNAIFKALQA DSPQSSSSIS EVHSPGEHSG QSQGPPTPPT TPKTDAQQPG KQDLKREGPL AEGGRQPPHI DFRDVDIGEL SSDVISNIET FDVNEFDQYL PPNGHPGVPA THGQVTTYSG TYGISSSASS PAGAGHAWMA KQQPQPPQPP AQPPAQHTLP STEREQGPAQ QRPHIKTEQL SPSHNSEQQQ HPEQQQQQQQ QLGYGSFNLQ HYGFSYPPIT RSEYDYTEHQ NSGSYYSHAA GQSGSLYSTF TYMNPTQRPM YTPIADTSGV PTIPQTHSPQ QHWEQPVYTQ LTRP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination.
  • 基因功能参考文献：
    1. Avian digits may represent an evolutionary specialization of digit development consequence of a posterior polarization of signals responsible for limb outgrowth. In contrast, the pentadactyl autopod of mouse and turtle embryos may result from the uniform expansion (like opening a fan) of the signals that coordinate proliferation and differentiation of the skeletal progenitors. PMID: 28386540
    2. Mechanical stimulation enhances nuclear signals of the transcription factors Sox9 and CREB in a PKA and PP2A-dependent manner PMID: 24333667
    3. The results suggest that ETS1 and SOX9 may act as pan-neural crest regulators of the migratory cranial neural crest PMID: 24389048
    4. data suggest a model in which extracellular signals initiate phosphorylation of Sox9 and its cooperation with Snail2 to induce NCC delamination PMID: 23382206
    5. Sox9 mediates the direct conversion of tenocytes to chondrocytes through an intermediate state in which both differentiation programs are active. Sox9 is expressed in cartilage but is undetectable in limb tendons that express Scleraxis and Tenomodulin. PMID: 22510437
    6. NFIA is a transcription factor that plays a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis PMID: 22500632
    7. model whereby Sox and Nfi proteins bind to conserved Matn1 proximal elements and functionally interact with each other to finely tune gene expression in specific zones of the cartilage growth plate PMID: 21173167
    8. Results suggest that SOX9 is necessary and sufficient to specify pyloric sphincter epithelial properties. PMID: 15240557
    9. Data suggest that Sox9 and Nkx2.5 are regulated independently by bone morphogenetic protein signaling, and act coordinately to specify the pyloric sphincter. PMID: 15733673
    10. PD098059 attenuated the depletion of cartilage matrix as well as decreased the expression and phosphorylation of Sox9 in cultures treated with H(2)O(2) or cyclosporine. PMID: 15777799
    11. Results demonstrate that RhoA-mediated modulation of actin polymerization regulates the ability of Sox9 to both activate chondrocyte-specific markers and maintain its own expression in chondrocytes via a positive feedback loop. PMID: 19470758

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: gga:374148

    STRING: 9031.ENSGALP00000037718

    UniGene: Gga.890