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  4. Recombinant Chicken Transforming growth factor beta-3 (TGFB3)

Recombinant Chicken Transforming growth factor beta-3 (TGFB3)

  • 货号：
    CSB-YP023449CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023449CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023449CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023449CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023449CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    TGFB3; Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide; LAP); Transforming growth factor beta-3; TGF-beta-3)]
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-300
  • 氨基酸序列
    LSSCTTL DLEHIKKKRV EAIRGQILSK LRLTSPPESV GPAHVPYQIL ALYNSTRELL EEMEEEKEES CSQENTESEY YAKEIHKFDM IQGLPEHNEL GICPKGVTSN VFRFNVSSAE KNSTNLFRAE FRVLRVPNPS SKRSEQRIEL FQILRPDEHI AKQRYLSGRN VQTRGSPEWL SFDVTDTVRE WLLHRESNLG LEISIHCPCH TFQPNGDILE NLHEVLEIKF KGIDSEDDYG RGDLGRLKKQ KDLHNPHLIL MMLPPHRLES PTLGGQRKKR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.; Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
  • 基因功能参考文献：
    1. The single nucleotide polymorphism and analyzed haplotypes identified in this study might be used as potential genetic markers in meat-type chicken breeding. PMID: 23776260
    2. MBNL1 negatively regulates cell invasion in the endocardial cushions by restricting the magnitude and timing of endocardial-derived TGFbeta3 production. PMID: 22866814
    3. Data show that bone morphogenetic proteins/TGFbetas/Wnts are necessary to regulate pattern formation and the specification of neural progenitor populations in the dorsal neural tube. PMID: 15385163
    4. TGFB3 inhibits chondrogenesis of cultured chicken leg bud mesenchymal cells via downregulation of connexin 43 and integrin beta4. PMID: 17620312
    5. TGF-beta1, TGF-beta2, TGF-beta3 have different roles in the embryonic nervous system of mouse and chicken PMID: 18498095
    6. gene expression and production of TGF-beta are high and are upregulated in healing tendon PMID: 19084187
    7. immunohistochemical localization of TGF-beta1, -2, and -3 in chick corneas during fibrotic wound repair PMID: 19626665

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  • 亚细胞定位：
    [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix.; [Transforming growth factor beta-3]: Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    KEGG: gga:396438

    STRING: 9031.ENSGALP00000036912

    UniGene: Gga.42150