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  4. Recombinant Danio rerio Fibroblast growth factor receptor 1-A (fgfr1a), partial

Recombinant Danio rerio Fibroblast growth factor receptor 1-A (fgfr1a), partial

  • 货号：
    CSB-YP820906DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP820906DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP820906DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP820906DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP820906DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    fgfr1a
  • Uniprot No.：
  • 别名：
    fgfr1a; fgfr1; si:ch211-198o12.1Fibroblast growth factor receptor 1-A; FGFR-1-A; bFGF-R-1-A; EC 2.7.10.1; Basic fibroblast growth factor receptor 1-A
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.
  • 基因功能参考文献：
    1. Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays PMID: 26931467
    2. we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage. PMID: 24176552
    3. Considering all these findings, we concluded that as in mammals, in adult zebrafish the metabolism of lipid and bile acids in the liver are regulated by Fgf signaling. PMID: 22820869
    4. Data indicate that fgf20a, fgf24, FGF receptor fgfr1 are expressed in normal and regenerating barbel tissue. PMID: 23350700
    5. Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish. PMID: 23136387
    6. Requirement of Fgf signaling to maintain photoreceptors and for proliferation during regeneration in the adult zebrafish retina. PMID: 22291943
    7. Mutation of the gene encoding Fgfr1a simultaneously increases aggression, boldness, and exploration in adult zebrafish. PMID: 21957242
    8. fgfr expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis. PMID: 20960516
    9. we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1). PMID: 15221377
    10. knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration PMID: 16273523
    11. Bmp and Fgf signaling are essential for liver specification in zebrafish. PMID: 17507405

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
  • 组织特异性：
    Initially expressed in adaxial mesoderm with transcripts distinctly localized to the anterior portion of each half-somite. Hereupon, also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundar
  • 数据库链接：

    KEGG: dre:30705

    STRING: 7955.ENSDARP00000069260

    UniGene: Dr.78806