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  4. Recombinant Danio rerio Transcription factor Sox-2 (sox2)

Recombinant Danio rerio Transcription factor Sox-2 (sox2)

  • 货号：
    CSB-YP761266DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP761266DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP761266DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP761266DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP761266DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    sox2; zgc:65860; zgc:77389; Transcription factor Sox-2
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-315
  • 氨基酸序列
    MYNMMETELK PPAPQPNTGG TGNTNSSGNN QKNSPDRIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS ESEKRPFIDE AKRLRALHMK EHPDYKYRPR RKTKTLMKKD KYTLPGGLLA PGGNGMGAGV GVGAGLGAGV NQRMDSYAHM NGWTNGGYGM MQEQLGYPQH PSLNAHNTAQ MQPMHRYDMS ALQYNSMTNS QTYMNGSPTY SMSYSQQSTP GMTLGSMGSV VKSESSSSPP VVTSSSHSRA GQCQTGDLRD MISMYLPGAE VQDQSAQSRL HMSQHYQSAP VPGTTINGTI PLSHM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal.
  • 基因功能参考文献：
    1. Findings indicate a pivotal role for ZNF32 function in SOX2 expression and regeneration regulation. PMID: 27626680
    2. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration. PMID: 26609166
    3. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury PMID: 25150399
    4. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. PMID: 24498133
    5. By western blot three protein bands of 28 kDa, 34 kDa (main band), and 38 kDa were detected in the brain of animals 180 days post-fertilizaton. PMID: 20734413
    6. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos. PMID: 21820425
    7. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration PMID: 20025865
    8. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs PMID: 19800392
    9. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line PMID: 17443814
    10. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters. PMID: 19767420

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    At the shield stage, expressed uniformly in the future ectoderm. At the 75-80% epiboly stage, becomes localized to the presumptive neuroectoderm; strong expression in the presumptive forebrain, weak expression in the presumptive spinal cord. At the tail b
  • 数据库链接：

    KEGG: dre:378723

    STRING: 7955.ENSDARP00000095266

    UniGene: Dr.5379