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  4. Recombinant Dog Heat shock factor protein 4 (HSF4)

Recombinant Dog Heat shock factor protein 4 (HSF4)

  • 货号：
    CSB-YP626195DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP626195DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP626195DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP626195DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP626195DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HSF4
  • Uniprot No.：
  • 别名：
    HSF4; Heat shock factor protein 4; HSF 4; Heat shock transcription factor 4; HSTF 4
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-492
  • 氨基酸序列
    MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK VPALRSDDGR WRPEDLGRLL GEVQALRGVQ EITEARLREL RQQNEILWRE VVTLRQSHGQ QHRVIGKLIQ CLFGPLQTGS SGAGAKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF IQSPLPETTL GLSSSHRTRG PIISDIHEDS PSPDGTRLSP SSGGRREKGL ALLKEEPASP GGEGEAGLAL APNECDFCVT APPPLSVAVV QAILEGKGNF SPEGPRNAQQ PEPRGPREVP DRGTLGLDRG ARSPENLLPP MLLRAPPESV EPAGPLDVLG PSHQGREWTL MDLDMELSLM QPLGPERSET ELAVKGLNSP GPGKDSTLGA PLLLDVQAAL GGPALSLPGA LTIYSTPESR ANYLGPGANP SP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that specifically binds heat shock promoter elements (HSE).
  • 基因功能参考文献：
    1. Deletion of HSF4 is significantly associated with cataracts and a dog carrying the mutation is approximately 17 times more likely to develop binocular cataracts than dogs that are clear of the mutation. PMID: 19883468
    2. HSF4 is not associated with the development of the late-onset form of cataract and the 2 forms of cataract in Boston Terriers are therefore genetically discrete conditions. PMID: 17611257
    3. Article could not verify that the mutation in exon 9 of canine HSF4 gene is causative for primary cataracts in dog breeds. PMID: 17651328
    4. We found a single nucleotide polymorphism in intron 9 which was neither associated nor linked with the CAT phenotype in the two dog breeds PMID: 18190350
    5. insertion/deletion mutations in exon 9 of heat shock transcription factor 4 are not responsible for juvenile hereditary cataract in Siberian Husky dogs PMID: 18680491

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  • 相关疾病：
    Defects in HSF4 are a cause of forms of hereditary cataract (HC) in dogs. Mutations in HSF4 seem to be causing a recessive form of cataract in Staffordshire Bull terriers and Boston terriers and a dominant cataract in Australian shepherds.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HSF family
  • 数据库链接：

    KEGG: cfa:489766

    STRING: 9615.ENSCAFP00000030227

    UniGene: Cfa.25663