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  4. Recombinant Dog Inactive pancreatic lipase-related protein 1 (PNLIPRP1)

Recombinant Dog Inactive pancreatic lipase-related protein 1 (PNLIPRP1)

In Stock
  • 中文名称：
    Recombinant Dog Inactive pancreatic lipase-related protein 1(PNLIPRP1)
  • 货号：
    CSB-EP018263DO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    PNLIPRP1
  • Uniprot No.：
  • 别名：
    PNLIPRP1; PLRP1; Inactive pancreatic lipase-related protein 1; PL-RP1
  • 种属：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    65.7kDa
  • 表达区域：
    18-467aa
  • 氨基酸序列
    KEVCYEQIGCFSDAEPWAGTAIRPLKVLPWSPERIGTRFLLYTNKNPNNFQTLLPSDPSTIEASNFQTDKKTRFIIHGFIDKGEENWLLDMCKNMFKVEEVNCICVDWKKGSQTSYTQAANNVRVVGAQVAQMLSMLSANYSYSPSQVQLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEASFQGTPEEVRLDPTDADFVDVIHTDAAPLIPFLGFGTSQQMGHLDFFPNGGEEMPGCKKNALSQIVDLDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYRAFESNKCFPCPDQGCPQMGHYADKFAVKTSDETQKYFLNTGDSSNFARWRYGVSITLSGKRATGQAKVALFGSKGNTHQFNIFKGILKPGSTHSNEFDAKLDVGTIEKVKFLWNNNVVNPTFPKVGAAKITVQKGEEKTVHSFCSESTVREDVLLTLTPC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The process of expressing this Dog PNLIPRP1 recombinant protein in E.coli expression system requires the following steps: use of competent E. coli cells to take up DNA sequence of interest, the exogenous plasmid is transferred into the cell, and the transcription and translation are directly replicated in the cell, selection of transformed E. coli using a selection marker, expansion of selected E. coli to a higher scale in appropriate culture media, such as classic LB options Growth Systems and lastly isolation and purification.And we finally get a PNLIPRP1 protein with N-terminal 6xHis-SUMO tag and it is determined by SDS-PAGE with a purity of 90%+.

    PNLIPRP1 (PLRP1) is a protein coding gene that encodes Inactive pancreatic lipase-related protein 1. According to some studies, PNLIPRP1 may have the following features.
    The loss of PNLIPRP1 and NR1I3 was mainly associated with specific eating habits. The exons of these diabetic patients showed the rs2305205 mutation in the PNLIPRP1 gene and the rs778701848 mutation in the CAMKK2 gene. PNLIPRP1 showed no lipase activity against all known substrates. PNLIPRP1 acts as a negative regulator of pancreatic lipase activity by competing with PL to occupy colonic lipase.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro).
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 组织特异性：
    Detected in pancreas (at protein level).
  • 数据库链接：

    KEGG: cfa:404010

    STRING: 9615.ENSCAFP00000017453

    UniGene: Cfa.3881